13,14-DIHYDROPROSTAGLANDIN E1 Chemical Properties

Boiling point:

575.3±50.0 °C(Predicted)

Density 

1.191±0.06 g/cm3(Predicted)

RTECS 

UK8428300

storage temp. 

−20°C

solubility 

ethanol: 10 mg/mL, clear, faintly yellow

pka

4.69±0.10(Predicted)

form 

White to off-white solid.

color 

White to off-white

BRN 

2821925

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

F 

8-10

HS Code 

2937909000

MSDS

• Language:English Provider:SigmaAldrich

13,14-DIHYDROPROSTAGLANDIN E1 Usage And Synthesis

Description

6-keto prostaglandin F_1α (6-keto PGF_1α) is the inactive, non-enzymatic hydrolysis product of PGI₂. 6-keto PGF_1α serves as a useful marker of PGI₂ biosynthesis in vivo. When [³H]-PGI₂ is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [³H]-6-keto PGF_1α.

Uses

6-Ketoprostaglandin F1α is the stable hydrolysis product of prostacyclin (P839060), an eicosanoid which prevents the formation of platelet plugs and an effective vasodilator.

Definition

ChEBI: A prostaglandin Falpha that is prostaglandin F1alpha bearing a keto substituent at the 6-position.

IC 50

Human Endogenous Metabolite

References

[1] PACE-ASCIAK C. Isolation, structure, and biosynthesis of 6-ketoprostaglandin F1.alpha. in the rat stomach[J]. Journal of the American Chemical Society, 1976, 98 8: 2348-2349. DOI: 10.1021/ja00424a065
[2] ROY A. JOHNSON. The chemical structure of prostaglandin X (prostacyclin)[J]. Prostaglandins, 1976, 12 6: Pages 915-928. DOI: 10.1016/0090-6980(76)90126-x
[3] A R BRASH. Metabolic disposition of prostacyclin in humans.[J]. Journal of Pharmacology and Experimental Therapeutics, 1983, 226 1: 78-87.
[4] MALARVIZHI GURUSAMY. Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice.[J]. Journal of Translational Medicine, 2021: 340. DOI: 10.1186/s12967-021-03016-9

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