GUANETHIDINE HEMISULFATE
GUANETHIDINE HEMISULFATE Basic information
- Product Name:
- GUANETHIDINE HEMISULFATE
- Synonyms:
-
- guanetidinsulfate
- isobarin
- nsc-29863
- octadin
- octadine
- octatensin
- su-5864
- Guanidine, N-[2-(hexahydro-1(2H)-azocinyl)ethyl]-, sulfate (2:1)
- CAS:
- 60-02-6
- MF:
- C10H22N4.1/2H2O4S
- MW:
- 494.7
- EINECS:
- 200-452-0
- Product Categories:
-
- Amines
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 60-02-6.mol
GUANETHIDINE HEMISULFATE Chemical Properties
- Melting point:
- 255-265°C
- Density
- 1.1052 (rough estimate)
- refractive index
- 1.7400 (estimate)
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White
- Merck
- 4560
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 60-02-6
Safety Information
- Safety Statements
- 24/25
- RTECS
- MF3240000
GUANETHIDINE HEMISULFATE Usage And Synthesis
Chemical Properties
White Solid
Originator
Ismelin,Ciba,US,1960
Uses
Antihypertensive; antiglaucoma
Definition
ChEBI: A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.
Manufacturing Process
13.6 grams of chloroacetyl guanide is added while stirring to a solution of 22.6 grams of heptamethylene imine in 200 ml of benzene. After warming for 1 hour, and then cooling, the solution is filtered and the filtrate concentrated under reduced pressure. The residue, containing the 2-(1-N,N-heptamethylene-imino)-aceticacid guanide, is suspended in tetrahydrofuran and added to a refluxing solution of 6 grams of lithium aluminum hydride in tetrahydrofuran. After completion of the reaction, the excess of lithium aluminum hydride is decomposed by adding water, then aqueous sodium hydroxide. The solid material is filtered off, the filtrate is acidified with sulfuric acid and the 2-(1-N,N-heptamethylene-imino)-ethyl-guanidine sulfate can be recovered and recrystallized from aqueous ethanol, MP 276° to 281°C (with decomposition).
Therapeutic Function
Antihypertensive
GUANETHIDINE HEMISULFATESupplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 18521735133 18521732826;
- market@aladdin-e.com
- Tel
- +86 18953170293
- sales@sdzschem.com
- Tel
- 0551-65418671
- sales@tnjchem.com
GUANETHIDINE HEMISULFATE(60-02-6)Related Product Information
- Cleaning agent
- GUANETHIDINE SULFATE 2:1
- GUANETHIDINE SULFATE USP(CRM STANDARD)
- GUANETHIDINE HEMISULFATE
- guanethidine
- hexahydro-2H-azocine-1-ethylamine
- GUANETHIDINE SULFATE
- 1,7-HEPTANEDIOL
- Guanidine sulfate
- N-(2-DIETHYLAMINO-ETHYL)-GUANIDINE
- [2-(Diethylamino)ethyl]guanidinium sulfate
- N-ETHYLGUANIDINIUM SULFATE
- 1-METHYLGUANIDINE SULFATE