AM2394
AM2394 Basic information
- Product Name:
- AM2394
- Synonyms:
-
- AM2394
- 1-(6'-(2-hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea
- AM2394;AM 2394
- CS-2242
- N-[6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methylurea
- Urea, N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl-
- AM-2394,Hexokinase D,Inhibitor,AM 2394,Glucokinase,inhibit,Hexokinase IV
- AM-2394, 10 mM in DMSO
- CAS:
- 1442684-77-6
- MF:
- C22H25N5O4
- MW:
- 423.46
- Product Categories:
-
- API
- Mol File:
- 1442684-77-6.mol
AM2394 Chemical Properties
- Boiling point:
- 588.8±50.0 °C(Predicted)
- Density
- 1.266±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml
- form
- A crystalline solid
- pka
- 12.66±0.70(Predicted)
- color
- White to off-white
AM2394 Usage And Synthesis
Uses
AM 2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates GK with an EC50 of 60 nM.
Uses
AM 2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates GK with an EC50 of 60 nM.
in vivo
AM-2394, a structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in ob/ob mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. AM-2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animal models[1].
AM2394Supplier
- Tel
- 18062115889
- 405368533@qq.com
- Tel
- sales@boylechem.com
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Tel
- 025-846993838003-8003 18013301590
- njduly@126.com