NIH-12848 Chemical Properties

Boiling point:

441.6±45.0 °C(Predicted)

Density 

1.384±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: 25 mg/mL

form 

A crystalline solid

pka

5.05±0.30(Predicted)

color 

White to off-white

InChI

1S/C20H14F3N3S/c21-20(22,23)16-9-3-1-7-14(16)19-25-17-10-4-2-8-15(17)18(26-19)24-12-13-6-5-11-27-13/h1-11H,12H2,(H,24,25,26)

InChIKey

QBDAEJRHUCSSPR-UHFFFAOYSA-N

SMILES

FC(F)(F)c1c(cccc1)c2nc3c(c(n2)NCc4[s]ccc4)cccc3

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

NIH-12848 Usage And Synthesis

Uses

NIH-12848 is a a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor, and also a potentially powerful tool for exploring the cell physiology of PI5P4Ks. Reagent in the synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amines as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer.

Biological Activity

Cell permeable: yes', 'Primary Target
PI5P4Kγ', 'Reversible: yes