NCB-0846
NCB-0846 Basic information
- Product Name:
- NCB-0846
- Synonyms:
-
- CS-2514
- NCB0846;NCB 0846
- NCB-0846
- cis-4-[[2-(1H-Benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-cyclohexanol
- Cyclohexanol, 4-[[2-(1H-benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-, cis-
- cis-4-((2-((1H-Benzo[d]imidazol-6-yl)amino)quinazolin-8-yl)oxy)cyclohexanol
- Wnt,MAPK Kinase Kinase Kinase,NCB0846,Inhibitor,inhibit,MAP4K,NCB-0846
- Epoxiconazolet Impurity 5
- CAS:
- 1792999-26-8
- MF:
- C21H21N5O2
- MW:
- 375.42
- Mol File:
- 1792999-26-8.mol
NCB-0846 Chemical Properties
- Boiling point:
- 726.2±70.0 °C(Predicted)
- Density
- 1.415±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 12.87±0.30(Predicted)
- color
- Off-White to Light Yellow
- CAS DataBase Reference
- 1792999-26-8
NCB-0846 Usage And Synthesis
Uses
cis-4-?[[2-?(1H-?Benzimidazol-?6-?ylamino)?-?8-?quinazolinyl]?oxy]?-?cyclohexanol inhibits Traf2 and Nck-interacting protein kinase (TNIK). TNIK is involved with Canonical Wnt/b-catenin signalling, which has regulatory roles in maintaining intestinal stem cells and aberration in this pathway has been implicated in colorectal carcinogenesis. TNIK is a therapeutic target.
in vivo
NCB-0846 suppresses the growth of tumors established by inoculating HCT116 cells into immunodeficient mice. The expression of Wnt-target genes (AXIN2, MYC and CCND1) in xenografts is reduced following the administration of NCB-0846. NCB-0846 induces an increase in the sub-G1 cell population. Cleavage of poly (ADP-ribose) polymerase 1 indicates the induction of apoptosis[1].
IC 50
Wnt; TNIK: 21 nM (IC50)
NCB-0846Supplier
- Tel
- sales@boylechem.com
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Tel
- 400-400-164-7117 18317119277
- product02@bidepharm.com
- Tel
- 021-52996696，15000506266 15000506266
- Tel
- 021-65675885 18964387627
- info@efebio.com