2-FLUORONICOTINIC ACID METHYL ESTER Chemical Properties

Melting point:

22-26 °C

Boiling point:

75 °C/5 mmHg

Density 

1.243±0.06 g/cm3(Predicted)

Flash point:

110 °C

storage temp. 

Inert atmosphere,Room Temperature

pka

-2.47±0.10(Predicted)

form 

liquid

Appearance

Colorless to light yellow Liquid

InChIKey

PJNHJXKXBSOLBH-UHFFFAOYSA-N

CAS DataBase Reference

446-26-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

HS Code 

2933399990

2-FLUORONICOTINIC ACID METHYL ESTER Usage And Synthesis

Synthesis

GENERAL METHOD: To a solution of methyl 2-chloronicotinate (1.00 g, 6.76 mmol) in DMSO (33.8 mL) was added CsF (2.053 g, 13.51 mmol) at room temperature. The reaction mixture was stirred at 110 °C for 20 h in air. Upon completion of the reaction, the reaction mixture was quenched with ice water and extracted with EtOAc (3 × 20 mL). The organic layers were combined, washed sequentially with water and saturated brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: hexane/EtOAc gradient elution) to afford methyl 2-fluoronicotinate (0.639 g, 4.86 mmol, 71.9% yield) as a colorless oil. The synthesis of compounds 3B'-8B' was carried out with reference to the preparation steps of 2B'.

References

[1] Tetrahedron Letters, 2015, vol. 56, # 44, p. 6043 - 6046

2-FLUORONICOTINIC ACID METHYL ESTER(446-26-4)Related Product Information

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