2-FLUORO-3-(HYDROXYMETHYL)PYRIDINE Chemical Properties

Boiling point:

249℃

Density 

1.262

Flash point:

105℃

storage temp. 

Inert atmosphere,2-8°C

pka

12.94±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

CAS DataBase Reference

131747-55-2(CAS DataBase Reference)

Safety Information

HS Code 

2933399990

2-FLUORO-3-(HYDROXYMETHYL)PYRIDINE Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-fluoro-3-hydroxymethylpyridine using 2-fluoro-3-pyridinecarboxaldehyde as starting material: sodium borohydride (1.0 g, 26 mmol) was slowly added to a solution of 2-fluoro-3-pyridinecarboxaldehyde (1.6 mL, 16 mmol) in ethanol (14 mL), and the reaction mixture was stirred for 1 hour at room temperature. Upon completion of the reaction, water was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to afford the target product 2-fluoro-3-hydroxymethylpyridine (1.3 g, 10 mmol, 63% yield) as a colorless oil.

References

[1] Patent: EP3333163, 2018, A1. Location in patent: Paragraph 1401; 1402
[2] Patent: WO2010/132999, 2010, A1. Location in patent: Page/Page column 98
[3] Patent: WO2011/48082, 2011, A1. Location in patent: Page/Page column 88
[4] Organic Letters, 2017, vol. 19, # 14, p. 3895 - 3898

2-FLUORO-3-(HYDROXYMETHYL)PYRIDINE(131747-55-2)Related Product Information

• 6-FLUORO-2-METHYLNICOTINIC ACID
• 2-FLUORO-4-IODONICOTINIC ACID
• 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER
• 5-chloro-2-fluoro-3-Pyridinemethanol
• 2,6-Difluoropyridine-3-carboxylic acid
• 4,6-Difluoronicotinic acid
• 6-Fluoronicotinic acid
• 5-CHLORO-2-FLUORONICOTINIC ACID
• 2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE
• 2-Fluoronicotinic acid
• 2-FLUORONICOTINIC ACID METHYL ESTER
• 2-FLUORO-3-METHYL-PYRIDINE-5-CARBOXYLIC ACID
• 6-FLUORONICOTINIC ACID METHYL ESTER
• 6-Chloro-3-fluoro-2-(hydroxymethyl)pyridine
• 2-FLUORO-5-(HYDROXYMETHYL)PYRIDINE,6-Fluoro-3-(Hydroxymethyl)Pyridine
• 2-CHLORO-5-FLUORO-4-(HYDROXYMETHYL)PYRIDINE
• 2-CHLORO-5-FLUORO-3-(HYDROXYMETHYL)PYRIDINE
• 3-Pyridinemethanol