Pyrazinecarbonitrile Chemical Properties

Melting point:

18-20°C

Boiling point:

87 °C/6 mmHg (lit.)

Density 

1.174 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.534(lit.)

Flash point:

206 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Acetonitrile (Slightly), Chloroform (Slightly)

form 

Liquid

pka

-1.97±0.10(Predicted)

color 

Clear colorless to yellow

Water Solubility 

Slightly soluble in water.

BRN 

110008

Exposure limits

NIOSH: IDLH 25 mg/m3

InChI

1S/C5H3N3/c6-3-5-4-7-1-2-8-5/h1-2,4H

InChIKey

PMSVVUSIPKHUMT-UHFFFAOYSA-N

SMILES

N#Cc1cnccn1

LogP

-0.010

CAS DataBase Reference

19847-12-2(CAS DataBase Reference)

NIST Chemistry Reference

Cyanopyrazine(19847-12-2)

EPA Substance Registry System

2-Cyanopyrazine (19847-12-2)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

RIDADR 

3276

WGK Germany 

3

Hazard Note 

Irritant

TSCA 

TSCA listed

HazardClass 

6.1

PackingGroup 

III

HS Code 

29339990

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:Pyrazinecarbonitrile
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Pyrazinecarbonitrile Usage And Synthesis

Chemical Properties

Colorless liquid

Uses

Pyrazinenitrile (Pyrazinamide EP Impurity) is used as a single-source precursor in the synthesis of metal-free nitrogen-doped carbon nanoparticles (NCNPs). Also, it is an important intermediate in the production of pyrazinamide as an effective anti-tubercular drug.

Definition

ChEBI: Cyanopyrazine is a member of pyrazines and a nitrile.

Synthesis

2-cyanopyrazine was prepared from 2-methylpyrazine with iron phosphate catalyst by vapor phase catalytic ammoxidation in a fixed-bed reactor.

References

[1] Collection of Czechoslovak Chemical Communications, 1996, vol. 61, # 7, p. 1093 - 1101
[2] Patent: CN104557357, 2018, B. Location in patent: Paragraph 0150; 0151; 0152; 0160
[3] Chemical Communications, 2007, # 3, p. 301 - 303
[4] Bulletin des Societes Chimiques Belges, 1988, vol. 97, # 10, p. 731 - 742
[5] Patent: US2009/292122, 2009, A1. Location in patent: Page/Page column 12-13

Pyrazinecarbonitrile(19847-12-2)Related Product Information

• Sulfachoropyrazine sodium
• Pyrazinamide
• Glipizide
• 3-Chloropyrazine-2-carbonitrile
• 2,3-DICYANO-5-METHYLPYRAZINE
• 5,6-DICHLORO-2,3-DICYANOPYRAZINE
• 5,6-DIAMINO-2,3-DICYANOPYRAZINE
• 2,3-DICYANOPYRAZINE
• 5-Methyl-2-pyrazinecarbonitrile,Pyrazinecarbonitrile, 5-methyl- (9CI)
• Pyrazinecarbonitrile, 3-(1-piperazinyl)- (9CI)
• 5-BROMOPYRAZINE-2-CARBONITRILE
• 3-(1H-Imidazol-1-yl)-pyrazinecarbonitrile
• 2-BROMO-6-CYANOPYRAZINE
• 2-CHLORO-5-CYANOPYRAZINE
• Pyrazinecarbonitrile, 6-amino- (9CI)
• 2-AMINO-5-CYANOPYRAZINE
• 3-AMINO-2-QUINOXALINECARBONITRILE
• 5,6-DIMETHYL-2,3-PYRAZINEDICARBONITRILE