2-Methoxy-5-nitrophenol Chemical Properties

Melting point:

103-107 °C (lit.)

Boiling point:

110-112 °C/1 mmHg (lit.)

Density 

1.3375 (estimate)

refractive index 

1.5830 (rough estimate)

Flash point:

110-112°C/1mm

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

8.31±0.19(Predicted)

color 

Light Yellow to Light Brown

BRN 

2047074

InChIKey

KXKCTSZYNCDFFG-UHFFFAOYSA-N

CAS DataBase Reference

636-93-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26-36

RIDADR 

2811

WGK Germany 

3

Hazard Note 

Irritant

PackingGroup 

III

HS Code 

29095090

MSDS

• Language:English Provider:2-Methoxy-5-nitrophenol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Methoxy-5-nitrophenol Usage And Synthesis

Chemical Properties

Yellow to light brown powder

Uses

2-Methoxy-5-nitrophenol is used in the synthesis of potent VEGF and tyrosine kinase inhibitors. Also used in the synthesis of GABA analogues and phosphodiesterase inhibitors such as rolipram.

Definition

ChEBI: 2-Methoxy-5-nitrophenol is a member of 3-nitrophenols.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 28, p. 1287, 1980 DOI: 10.1248/cpb.28.1287

General Description

2-Methoxy-5-nitrophenol is the substitution photoproduct formed on irradiation of 2-chloro-4-nitroanisole at 25°C in aqueous NaOH.

2-Methoxy-5-nitrophenol(636-93-1)Related Product Information

• Guaifenesin
• 2-Methoxy-5-nitropyridine
• 3-Nitrophenol
• 4-Ethyl-2-methoxyphenol
• 2-Methyl-5-nitrophenol
• Sulfogaiacol
• 4-tert-Butyl-2-nitrophenol
• 2-METHOXY-5-NITROPHENOL SODIUM SALT,SODIUM 2-METHOXY-5-NITROPHENOL
• Guaiacol
• 4-Hydroxy-3-methoxystyrene
• 2-Methoxy-4-methylphenol
• 2-Amino-4-nitro anisidine
• Nitrophenol
• 2,5-DINITROPHENOL
• TRITON
• 4-Nitrophenol
• Nitrobenzene
• 2-METHOXY-4-NITROPHENOL,o-Methoxy-p-nitrophenol