N-BENZOYL-4-PIPERIDONE Chemical Properties

Melting point:

55-59 °C (lit.)

Boiling point:

158-160 °C/0.2 mmHg (lit.)

Density 

1.1255 (rough estimate)

refractive index 

1.5440 (estimate)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

methylene chloride: soluble

pka

-1.45±0.20(Predicted)

form 

powder to crystal

color 

White to Light yellow

BRN 

158848

InChI

1S/C12H13NO2/c14-11-6-8-13(9-7-11)12(15)10-4-2-1-3-5-10/h1-5H,6-9H2

InChIKey

NZAXGZYPZGEVBD-UHFFFAOYSA-N

SMILES

O=C1CCN(CC1)C(=O)c2ccccc2

CAS DataBase Reference

24686-78-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Safety Statements 

24/25

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29333999

Storage Class

13 - Non Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

N-BENZOYL-4-PIPERIDONE Usage And Synthesis

Chemical Properties

light yellow granular powder or granules

Uses

1-Benzoyl-4-piperidone can be used as starting reagent in the synthesis of fentanyl.

Biochem/physiol Actions

1-Benzoyl-4-piperidone and 1-methyl-4-piperidone reacts with triethyl phosphono-acetate in the presence of excess base and yields both the endocyclic and exocyclic olefins.

Synthesis

4-Piperidone hydrochloride hydrate (7.68 kg) with potassium carbonate (20.7 kg), 0 ?? C., added to water (50 liters), stirred well, then added to dichloromethane (40 liters), and then added dropwise to a solution of benzoyloxycarbonylsuccinimide (12.4 kg) of dichloromethane (80 liters), and the reaction was carried out at room temperature for two hours. The reaction solution was partitioned and the aqueous layer was extracted with dichloromethane (2 x 15 liters), the organic phases were combined, dried over anhydrous sodium sulfate, and concentrated to give 11.5 kg of 1-benzoyl-4-piperidone in the form of a colorless oil.

N-BENZOYL-4-PIPERIDONE(24686-78-0)Related Product Information

• N-BENZOYL-4-PIPERIDONE
• 3-(4-OXOPIPERIDINE-1-CARBONYL)PHENYLBORONIC ACID
• 4-(4-OXOPIPERIDINE-1-CARBONYL)PHENYLBORONIC ACID
• N-(4'-CARBOXYLIC)BENZOYL-4-PIPERIDONE
• 4-Piperidinone
• 1-(4-CHLORO-BENZOYL)-PIPERIDIN-4-ONE
• methyl 1-benzoyl-4-oxopiperidine-3-carboxylate
• N-BOC-4-(4-OXO-PIPERIDINE-1-CARBONYL)ANILINE
• 1-(4-NITRO-BENZOYL)-PIPERIDIN-4-ONE
• CBI-BB ZERO/005785
• 1-(4-FLUORO-BENZOYL)-PIPERIDIN-4-ONE
• 4-(4-OXO-PIPERIDINE-1-CARBONYL)-BENZAMIDE
• 1-(3-THIOPHEN-3-YL-BENZOYL)-PIPERIDIN-4-ONE
• N-(4-CARBOXYLIC)BENZOYL-4-PIPERIDONE
• N-Anisoyl-4-piperidone
• 4-(4-OXO-PIPERIDINE-1-CARBONYL)ANILINE
• 1-(4-BROMO-BENZOYL)-PIPERIDIN-4-ONE
• 4-(4-OXO-PIPERIDINE-1-CARBONYL)-BENZONITRILE