4-Piperidinone Chemical Properties

Boiling point:

175.1±15.0 °C(Predicted)

Density 

1.001±0.06 g/cm3(Predicted)

pka

8.95±0.20(Predicted)

form 

solid

color 

yellow

CAS DataBase Reference

41661-47-6(CAS DataBase Reference)

Safety Information

Risk Statements 

11-20/21/22

Safety Statements 

16-26-36/37/39

RIDADR 

1993

HazardClass 

IRRITANT

HS Code 

2914390090

4-Piperidinone Usage And Synthesis

Description

4-Piperidinone is a derivative of piperidine with the molecular formula C5H9NO. 4-Piperidone is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs.
Piperidones are a class of chemical compounds sharing the piperidone skeleton. A classic named reaction for the synthesis of piperidones is the Petrenko-Kritschenko piperidone synthesis which involves combining an alkyl-1,3-acetonedicarboxylate with benzaldehyde and an amine. This multicomponent reaction is related to the Hantzsch pyridine synthesis.

Uses

4-Piperidone monohydrate hydrochloride was used in the generation of compound libraries based on sub-reactions of an Ugi multicomponent reaction (MCR).

4-Piperidinone(41661-47-6)Related Product Information

• 1-Methyl-4-piperidone
• 2,2,6,6-Tetramethyl-4-piperidinol
• DROPERIDOL
• Triacetonediamine
• N-Carbethoxy-4-piperidone
• Haloperidol
• N-Benzyl-4-piperidone
• 1-N-BOC-4-PIPERIDINONE
• 4,4-Piperidinediol hydrochloride
• Diphenoxylate
• 1-Phenethyl-4-piperidone
• 2,2,6,6-Tetramethyl-4-piperidone hydrochloride
• (+/-)-exo-6-Hydroxytropinone
• N-Acetyl-4-piperidone
• Triacetonamine
• Ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride
• (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane
• 3,5-Dibromo-4-oxo-2,2,6,6-tetramethylpiperidin-1-yl