4-HYDROXYMETHYL-5-METHYLIMIDAZOLE Chemical Properties

Melting point:

136°C

Boiling point:

389.1±27.0 °C(Predicted)

Density 

1.231

storage temp. 

2-8°C

solubility 

DMSO (Heated), Methanol (Slightly)

form 

Solid

pka

13.62±0.10(Predicted)

color 

White to Off-White

Water Solubility 

almost transparency

InChI

InChI=1S/C5H8N2O/c1-4-5(2-8)7-3-6-4/h3,8H,2H2,1H3,(H,6,7)

InChIKey

AXJZCJSXNZZMDU-UHFFFAOYSA-N

SMILES

C1NC(CO)=C(C)N=1

LogP

-0.62 at 23℃ and pH8.4

CAS DataBase Reference

29636-87-1(CAS DataBase Reference)

EPA Substance Registry System

1H-Imidazole-4-methanol, 5-methyl- (29636-87-1)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

2933299090

4-HYDROXYMETHYL-5-METHYLIMIDAZOLE Usage And Synthesis

Uses

4-Hydroxymethyl-5-methylimidazole is used as an intermediate of Alosetron hydrochloride, a 5-HT3 antagonist used only for the treatment of irritable bowel syndrome (IBS) in women with predominantly severe diarrhoea. As the drug causes ischaemic colitis, a life-threatening condition in which intestinal tissue dies due to lack of blood flow to the colon. Therefore, it is no longer used.

4-HYDROXYMETHYL-5-METHYLIMIDAZOLE(29636-87-1)Related Product Information

• (5-Ethyl-1H-imidazol-4-yl)methanol
• 2-Cyaniminothiazolidine
• N-Cyanoimido-S,S-dimethyl-dithiocarbonate
• CIMETIDINE SULPHOXIDE DIHYDROCHLORIDE
• 4-[[(2-aminoethyl)thio]methyl]-5-methylimidazole
• Cimetidine Amide Dihydrochloride
• Cimetidine
• N-Cyano-3-(cyanoaMino)-N'-Methyl-7,8-dithia-2,4,11-triazadodec-2-en-12-iMidaMide (CiMetidine IMpurity)
• 2-cyano-1,3-bis(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine
• N-Cyano-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]carbamimidic acid methyl ester
• N-cyano-N',N''-dimethylguanidine
• CIMETIDINE DIHYDROCHLORIDE IMP D
• Cysteamine hydrochloride
• Cimetidine Impurity 3
• 4,5-Imidazoledicarboxylic acid
• Dimethyl 4,5-imidazoledicarboxylate
• 4-Methyl-5-imidazolemethanol hydrochloride
• Imidazole-4-methanol