2,4-DINITRO-5-FLUOROANILINE Chemical Properties

Melting point:

185-190 °C(lit.)

Boiling point:

425.0±40.0 °C(Predicted)

Density 

1.681

refractive index 

1.3773

storage temp. 

2-8°C

pka

-4.54±0.10(Predicted)

form 

powder to crystal

color 

Light yellow to Yellow

CAS DataBase Reference

367-81-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

36/37/38-23-22

Safety Statements 

26-36-24/25

RIDADR 

2811

WGK Germany 

3

F 

1-8-10

Hazard Note 

Toxic

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29214200

MSDS

• Language:English Provider:SigmaAldrich

2,4-DINITRO-5-FLUOROANILINE Usage And Synthesis

Synthesis

General procedure for the synthesis of 5-fluoro-2,4-dinitroaniline from 1,5-difluoro-2,4-dinitrobenzene: 2.0 equivalents (1.02 mL) of ammonia were slowly added dropwise to a solution of 1.0 equivalents (4.0 mmol) of 1,5-difluoro-2,4-dinitrobenzene (DFDNB, 1) dissolved in 40 mL of THF under magnetic stirring. The reaction mixture was continued to be stirred at room temperature for 30 min. After removing the solvent by evaporation under reduced pressure, water was added to precipitate the product. The crude product 5-fluoro-2,4-dinitroaniline (2) was collected by filtration and washed well with water. The target product 5-fluoro-2,4-dinitroaniline was finally obtained in 99% yield and >99% purity by HPLC.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 14, p. 4189 - 4192
[2] Recueil des Travaux Chimiques des Pays-Bas, 1916, vol. 35, p. 142
[3] Chem. Zentralbl., 1913, vol. 84, # II, p. 760

2,4-DINITRO-5-FLUOROANILINE(367-81-7)Related Product Information

• 2,4-Dinitroaniline
• N,N-DIETHYL-2,4-DINITRO-5-FLUOROANILINE*
• 2,4-DINITRO-5-FLUOROANILINE
• (5-FLUORO-2,4-DINITRO-PHENYL)-METHYL-PHENYL-AMINE
• (S)-2-(5-fluoro-2,4-dinitrophenylaMino)propanaMide
• 2,4-DINITRO-5-FLUOROACETANILIDE
• 1-(5-FLUORO-2,4-DINITROPHENYL)-4-METHYLPIPERAZINE
• FDNP-D-ALA-NH2
• 3-(5-FLUORO-2,4-DINITROANILINO)-PROXYL
• N(ALPHA)-(2 4-DINITRO-5-FLUOROPHENYL)-
• FDNP-VAL-NH2
• NALPHA-(5-FLUORO-2,4-DINITROPHENYL)-D-LEUCINAMIDE
• NALPHA-(5-FLUORO-2,4-DINITROPHENYL)-L-LEUCINAMIDE