Ethyl L-tryptophanate hydrochloride Chemical Properties

Melting point:

220-225 °C (dec.)

alpha 

10 º (c=2% in H2O)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Powder

pka

pKa 7.10±0.05(H2O t=25.0±0.1 I=0.1(NaCl) N2atmosphere) (Uncertain);10.79±0.02 (H2O t=25.0±0.1 I=0.1(NaCl) N2atmosphere) (Uncertain)

color 

White to off-white

optical activity

[α]20/D +10±1°, c =2% in H2O

InChI

InChI=1/C13H16N2O2.ClH/c1-2-17-13(16)11(14)7-9-8-15-12-6-4-3-5-10(9)12;/h3-6,8,11,15H,2,7,14H2,1H3;1H/t11-;/s3

InChIKey

PESYCVVSLYSXAK-XAAIUDFWNA-N

SMILES

C12C=CC=CC=1NC=C2C[C@H](N)C(=O)OCC.Cl |&1:10,r|

CAS DataBase Reference

2899-28-7(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

Ethyl L-tryptophanate hydrochloride Usage And Synthesis

Chemical Properties

Light grey crystalline powder

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Preparation of Example 110 Ethyl L-tryptophan hydrochloride: L-tryptophan (14.3 g, 0.07 mol) was dissolved in 200 ml of ethanol containing about 7 g of anhydrous hydrogen chloride and the reaction was carried out at reflux for 5 hours. After completion of the reaction, the mixture was cooled and the precipitated solid was purified by recrystallization from a solvent mixture of ethanol/ether. The product was obtained as 17.4 g in 92.5% yield, melting point not provided. The product was chemically named L-2-amino-3-indolepropionic acid ethyl ester hydrochloride.

References

[1] Patent: US4824850, 1989, A

Ethyl L-tryptophanate hydrochloride(2899-28-7)Related Product Information

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