Basic information Safety Supplier Related

CARDIN

Basic information Safety Supplier Related

CARDIN Basic information

Product Name:
CARDIN
Synonyms:
  • (alpha-methylbutyryloxy)-3’-acetoxy-4’-dihydro-3’,4’-seselin
  • CARDIN
  • 2h,8h-benzo(1,2-b:3,4-b’)dipyran-2-one-acetate
  • 2-methyl-,9-esterwith9,10-dihydro-9,10-dihydroxy-8,8-dimethyl-butyricaci
  • 3-(alpha-methylbutyryloxy)-4-acetoxy-3,4-dihydroseseline
  • cardine
  • carduben
  • carduben-s
CAS:
477-32-7
MF:
C21H24O7
MW:
388.41
EINECS:
207-515-1
Product Categories:
  • Coumarins
Mol File:
477-32-7.mol
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CARDIN Chemical Properties

Melting point:
85-88°
alpha 
D20 +9.2° (alc); D30 +42.5° (c = 2 in dioxane)
Boiling point:
434.13°C (rough estimate)
Density 
1.2086 (rough estimate)
refractive index 
1.5300 (estimate)
storage temp. 
-20°C
CAS DataBase Reference
477-32-7
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Safety Information

Hazard Codes 
Xn,N
Risk Statements 
22-50
Safety Statements 
61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
Toxicity
LD50 in mice (mg/kg): 2240 orally; >370 s.c. (Erbring)
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CARDIN Usage And Synthesis

Originator

Vibeline ,Bellon ,France,1960

Uses

Visnadine is used as a coumarin scaffold for anti-inflammatory drug development, melanin biosynthetic inhibitory activity, anticellulite efficacy in female patient with cellulite blemish affected by fat accumulation or new anticellulite treatment.

Definition

ChEBI: Visnadin is a member of coumarins.

Manufacturing Process

Ammi visnaga is a plant of the Umbelliferae family, which has been known and used for its therapeutic properties by the peoples of the Mediterranean basin since time immemorial.
Visnadine may be extracted from the umbels of Ammi visnaga by an organic solvent having a boiling point less than 110°C. The resulting solution is concentrated first by heating in a water bath and then is allowed to stand some time at a temperature of about 20°C and if necessary is treated for separation of gummy constituents therefrom, after which the solution is concentrated under reduced pressure. Finally, the crude product is crystallized and separated by retaining it on a filter.
This crude product may then, according to the process, be purified by mixing it with petroleum ether and allowing it to stand at ordinary temperature, then filtering it to obtain the pure visnadine.

Therapeutic Function

Coronary vasodilator, Antiarrhythmic

CARDINSupplier

Shanghai Tauto Biotech Co., Ltd.
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021-51320588
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tauto@tautobiotech.com
Shanghai Yongye Biotechnology Co., Ltd.
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86-021-61559134 15921386130
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3423497944@qq.com
Wuhan ChemFaces Biochemical Co., Ltd.
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18607101326 15172504745
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aileen@chemfaces.com
Shanghai ChengShao Biological Technology Co., Ltd.
Tel
021-61847300 13341622919
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shcss01@163.com
Nanjing Digger Medical Technology Co. Ltd.
Tel
025-025-51191215 18013836722
Email
2399235533@qq.com