METHYL 5-BROMO-2-FUROATE Chemical Properties

Melting point:

63-68 °C

Boiling point:

80°C/0.7mmHg(lit.)

Density 

1.623±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Soluble), DMSO (Slightly)

form 

Crystalline Powder

color 

White to slightly yellow

Water Solubility 

Slightly soluble in water.

λmax

264nm(EtOH)(lit.)

InChIKey

FBPIDMAELBIRLE-UHFFFAOYSA-N

CAS DataBase Reference

2527-99-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26

HazardClass 

IRRITANT

HS Code 

29321900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

METHYL 5-BROMO-2-FUROATE Usage And Synthesis

Chemical Properties

White to slightly yellow crystalline powder

Uses

It is used in the preparation of hydroquinone bis(2-carbomethoxy-5-furyl ether).

Synthesis

General procedure for the synthesis of methyl 5-bromofuran-2-carboxylate from methanol and 5-bromo-2-furoic acid: 5-bromo-2-furoic acid (950 mg, 5.00 mmol) was accurately weighed and dissolved in 10 mL of methanol, and 2 mL of sulfoxide chloride (SOCl2) was added slowly and dropwise. Upon completion of the reaction, the reaction mixture was cooled to room temperature and the solvent was subsequently removed by evaporation under reduced pressure. The residue was dissolved in an appropriate amount of toluene and this dissolution and evaporation process was repeated three times to give the intermediate 5-bromo-2-furoic acid methyl ester in 100% yield.

References

[1] Patent: CN103992311, 2017, B. Location in patent: Paragraph 0103; 0104; 0105; 0106; 0123; 0124; 0125
[2] Organic Letters, 2012, vol. 14, # 22, p. 5644 - 5647
[3] Patent: CN106977476, 2017, A. Location in patent: Paragraph 0103-0105
[4] Patent: WO2015/159103, 2015, A1. Location in patent: Page/Page column 33; 34; 37
[5] Patent: WO2015/1024, 2015, A1. Location in patent: Page/Page column 65

METHYL 5-BROMO-2-FUROATE(2527-99-3)Related Product Information

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