Methyl 5-bromo-2-chloropyridine-3-carboxylate Chemical Properties

Melting point:

50-52°C

Boiling point:

275.6±35.0 °C(Predicted)

Density 

1.684±0.06 g/cm3(Predicted)

Flash point:

>110 °C

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

soluble in Methanol

pka

-3.78±0.10(Predicted)

form 

Solid

color 

White to Light yellow to Light orange

Sensitive 

Light, Air & Moisture Sensitive

InChIKey

MOMQDEDQGJAKII-UHFFFAOYSA-N

CAS DataBase Reference

78686-79-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933399990

Methyl 5-bromo-2-chloropyridine-3-carboxylate Usage And Synthesis

Crystal data

The crystal structure data of Methyl 5-bromo-2-chloropyridine-3-carboxylate is shown below:

Synthesis

Methyl 5-bromo-2-chloropyridine-3-carboxylate is prepared by the reaction of 5-Bromo-2-chloronicotinic acid and Methanol. The specific synthesis steps are as follows:
To 0.5 L flask charged with 5-Bromo-2-chloronicotinic acid (25.0 g, 106.4 mmol) in MeOH (250 mL) was added H2SO4(5 mL). The mixture was heated to 60° C., stirred for 1.5 day. LC-MS indicated full conversion of starting material at this time. The reaction was cooled to RT and the volatile components removed in vacuo. The crude residue was dissolved in EtOAc (300 mL), quenched with sat. aqueous Na(HCO3)2(200 mL). The organic layer was separated, washed with brine, dried over MgSO4and concentrated to afford the compound, methyl-5-bromo-2-chloronicotinate, as a while solid (quantitative yield). LC-MS (M+H)=250.1.

Methyl 5-bromo-2-chloropyridine-3-carboxylate(78686-79-0)Related Product Information

• Methylparaben
• RESMETHRIN
• Methyl 5-bromonicotinate
• 3-Bromoanisole
• Acetonitrile
• Chlorobromoisocyanurate
• CHLORODIBROMOMETHANE
• METHYL 2-CHLORONICOTINATE
• Methyl 6-chloronicotinate
• Methyl acrylate
• Methyl nicotinate
• Methanol
• 1-Bromo-3-chloro-5,5-dimethylhydantoin
• Basic Violet 1
• Kresoxim-methyl
• methyl 5-bromo-6-chloropyridine-3-carboxylate,Methyl 3-bromo-2-chloropyridine-5-carboxylate
• Methyl
• 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER