Methyl-5-bromo-2 pyrimidine carboxylate Chemical Properties

Melting point:

149°C(lit.)

Boiling point:

314.4±34.0 °C(Predicted)

Density 

1.669

storage temp. 

Inert atmosphere,Room Temperature

solubility 

soluble in Methanol

pka

-2.81±0.22(Predicted)

form 

Solid

color 

White

InChI

InChI=1S/C6H5BrN2O2/c1-11-6(10)5-8-2-4(7)3-9-5/h2-3H,1H3

InChIKey

XILAKTMDKMVJQV-UHFFFAOYSA-N

SMILES

C1(C(OC)=O)=NC=C(Br)C=N1

CAS DataBase Reference

89581-38-4

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

29335990

Methyl-5-bromo-2 pyrimidine carboxylate Usage And Synthesis

Uses

5-Bromopyrimidine-2-carboxylic Acid Methyl Ester is used in the study of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs)?.

Synthesis

5-Bromopyrimidine-2-carboxylic acid (3.22 g, 15.9 mmol) was dissolved in methanol (50 mL) at room temperature and acetyl chloride (4.0 mL, 56.3 mmol) was slowly added. The reaction mixture was heated to reflux, maintained for 15 min and then cooled to room temperature. Subsequently, the reaction mixture was concentrated under reduced pressure to remove the solvent. The concentrated mixture was diluted with saturated sodium bicarbonate solution (30 mL) and ethyl acetate and transferred to a partition funnel for separation. The aqueous phase was extracted repeatedly with ethyl acetate (4 x 30 mL) and all organic phases were combined. The organic phase was washed with saturated brine (1 × 30 mL), dried over anhydrous magnesium sulfate, filtered and concentrated to give methyl 5-bromo-2-pyrimidinecarboxylate (2.30 g, 10.6 mmol, 67% yield) as a white solid. Analyzed by LC/MS (ESI), m/z = 216.9 ([M+H]+) was measured, which is consistent with the calculated value of molecular weight 216.0 for C6H5BrN2O2.

References

[1] Patent: WO2014/138484, 2014, A1. Location in patent: Page/Page column 185; 186
[2] Patent: WO2016/22724, 2016, A1. Location in patent: Page/Page column 328
[3] Patent: WO2005/28452, 2005, A1. Location in patent: Page/Page column 88
[4] Patent: US2010/216806, 2010, A1. Location in patent: Page/Page column 96

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