AC-IETD-AFC
AC-IETD-AFC Basic information
- Product Name:
- AC-IETD-AFC
- Synonyms:
-
- CASPASE 8 SUBSTRATE 1F, FLUOROGENIC
- CASPASE-8 FLUOROGENIC SUBSTRATE
- GRANZYME B SUBSTRATE I, COLORIMETRIC
- AC-IETD-AFC
- AC-ILE-GLU-THR-ASP-7-AMINO-4-TRIFLUORO-METHYLCOUMARIN
- AC-ILE-GLU-THR-ASP-AFC
- N-ACETYL-ILE-GLU-THR-ASP-(7-AMINO-4-TRIFLUOROMETHYLCOUMARIN)
- N-ACETYL-ILE-GLU-THR-ASP-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN AFC
- CAS:
- 211990-57-7
- MF:
- C31H38F3N5O12
- MW:
- 729.65
- Product Categories:
-
- Caspase/Related Products
- peptide
- Caspases/Apoptosis
- Mol File:
- 211990-57-7.mol
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AC-IETD-AFC Chemical Properties
- Boiling point:
- 1113.8±65.0 °C(Predicted)
- Density
- 1.437±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO
- pka
- 4.09±0.10(Predicted)
- form
- Lyophilized powder
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AC-IETD-AFC Usage And Synthesis
Uses
N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin is a fluorogenic substrate for caspases -6, -8, and -10. The IETD sequence is based on the procaspase-3 cleavage site. Residues 172-175 of procaspase-3 are cleaved during apoptosis to produce the p12 subunit and a p20 peptide that is further cleaved to form the p17 subunit of mature caspase 3.
Uses
Ac-IETD-AFC is a fluorogenic substrate for caspase-8/caspase-3 processing enzyme and granzyme B. It is also a substrate for caspase-10. The IETD sequence is based on caspase-3 proenzyme cleavage site.
AC-IETD-AFCSupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
GL Biochem (Shanghai) Ltd
- Tel
- 21-61263452 13641803416
- ymbetter@glbiochem.com
Beijing Ouhe Technology Co., Ltd
- Tel
- 010-82967028 13552068683
- 2355560935@qq.com
VDM Biochemicals
- Tel
- 0330-2528181
- sales@vdmbio.com
Shanghai Changyan Chem & Tech Co., Ltd.
- Tel
- 021-021-20242659 18930833303
- order@changyanchem.com