Basic information Safety Supplier Related

AC-IETD-AFC

Basic information Safety Supplier Related

AC-IETD-AFC Basic information

Product Name:
AC-IETD-AFC
Synonyms:
  • CASPASE 8 SUBSTRATE 1F, FLUOROGENIC
  • CASPASE-8 FLUOROGENIC SUBSTRATE
  • GRANZYME B SUBSTRATE I, COLORIMETRIC
  • AC-IETD-AFC
  • AC-ILE-GLU-THR-ASP-7-AMINO-4-TRIFLUORO-METHYLCOUMARIN
  • AC-ILE-GLU-THR-ASP-AFC
  • N-ACETYL-ILE-GLU-THR-ASP-(7-AMINO-4-TRIFLUOROMETHYLCOUMARIN)
  • N-ACETYL-ILE-GLU-THR-ASP-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN AFC
CAS:
211990-57-7
MF:
C31H38F3N5O12
MW:
729.65
Product Categories:
  • Caspase/Related Products
  • peptide
  • Caspases/Apoptosis
Mol File:
211990-57-7.mol
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AC-IETD-AFC Chemical Properties

Boiling point:
1113.8±65.0 °C(Predicted)
Density 
1.437±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO
pka
4.09±0.10(Predicted)
form 
Lyophilized powder
color 
White to off-white
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AC-IETD-AFC Usage And Synthesis

Uses

N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin is a fluorogenic substrate for caspases -6, -8, and -10. The IETD sequence is based on the procaspase-3 cleavage site. Residues 172-175 of procaspase-3 are cleaved during apoptosis to produce the p12 subunit and a p20 peptide that is further cleaved to form the p17 subunit of mature caspase 3.

Uses

Ac-IETD-AFC is a fluorogenic substrate for caspase-8/caspase-3 processing enzyme and granzyme B. It is also a substrate for caspase-10. The IETD sequence is based on caspase-3 proenzyme cleavage site.

AC-IETD-AFCSupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Email
2355560935@qq.com
VDM Biochemicals
Tel
0330-2528181
Email
sales@vdmbio.com
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Email
Sales@changyanchem.cn
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AC-IETD-AFC(211990-57-7)Related Product Information