1,3-DICHLORO-5-[(1E)-2(4-TRIFLUOROMETHYLPHENYL)ETHENYL]-BENZENE Chemical Properties

Boiling point:

361.2±42.0 °C(Predicted)

Density 

1.378±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:1): .5 mg/ml; Ethanol: 20 mg/ml

form 

A crystalline solid

color 

White to off-white

1,3-DICHLORO-5-[(1E)-2(4-TRIFLUOROMETHYLPHENYL)ETHENYL]-BENZENE Usage And Synthesis

Description

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar. CAY10465 is an analog of resveratrol acting as a potent and selective AhR agonist, with a K_i of 0.2 nM. CAY10465 is inactive as a ligand for the estrogen receptor even at 100 μM.

Uses

(E)-1-[4-(Trifluoromethyl)phenyl]-2-(3,5-dichlorophenyl)ethene is a stilbene derivative of resveratrol and a selective aryl hydrocarbon receptor agonist.

References

[1] MICHAEL S DENISON  Scott R N. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.[J]. Annual review of pharmacology and toxicology, 2003, 43: 309-334. DOI: 10.1146/annurev.pharmtox.43.100901.135828
[2] PHILIPPE DE MEDINA. Synthesis and Biological Properties of New Stilbene Derivatives of Resveratrol as New Selective Aryl Hydrocarbon Modulators[J]. Journal of Medicinal Chemistry, 2004, 48 1: 287-291. DOI: 10.1021/jm0498194