GSK 2239633A
GSK 2239633A Basic information
- Product Name:
- GSK 2239633A
- Synonyms:
-
- GSK 2239633A
- Propanamide, N-[[3-[[3-[[(5-chloro-2-thienyl)sulfonyl]amino]-4-methoxy-1H-indazol-1-yl]methyl]phenyl]methyl]-2-hydroxy-2-methyl-
- GSK-2239633A,inhibit,Inhibitor,CC chemokine receptor,CCR,GSK2239633A
- N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide
- GSK2239633A, 10 mM in DMSO
- CAS:
- 1240516-71-5
- MF:
- C24H25ClN4O5S2
- MW:
- 549.06
- Mol File:
- 1240516-71-5.mol
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GSK 2239633A Chemical Properties
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:152.46(Max Conc. mg/mL);277.67(Max Conc. mM)
- form
- Solid
- pka
- 7.03±0.30(Predicted)
- color
- White to off-white
- InChIKey
- YTEVTHHGQMUPHC-UHFFFAOYSA-N
- SMILES
- C(NCC1=CC=CC(CN2C3=C(C(OC)=CC=C3)C(NS(C3SC(Cl)=CC=3)(=O)=O)=N2)=C1)(=O)C(O)(C)C
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GSK 2239633A Usage And Synthesis
Uses
GSK 2239633A, is an allosteric antagonist of human CCR4.
in vivo
Following intravenous dosing, plasma GSK2239633A displays rapid, bi-phasic distribution and slow terminal elimination (t1/2: 13.5 hours), suggesting that GSK2239633A is a low to moderate clearance drug. Following oral dosing, blood levels of GSK2239633A reach Cmax rapidly (median tmax: 1.0-1.5 hours). Estimated GSK2239633A bioavailability is low with a maximum value determined of only 16%[1]. GSK2239633A (Compound 9) demonstrates good pharmacokinetic data in preclinical animal studies (bioavailability in rats and beagle dogs 85% and 97% respectively)[3].
IC 50
[125I]-TARC-CCR4: 7.96 (pIC50)
storage
Store at -20°C
GSK 2239633ASupplier
Hangzhou ChangCun Biotechnology Co., Ltd. Gold
- Tel
- 0571-; 13567100326
- 158848739@qq.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
Amadis Chemical Company Limited
- Tel
- 571-89925085
- sales@amadischem.com
Aikon International Limited
- Tel
- 025-58851090 15955137747
- sales01@aikonchem.com
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