Basic information Safety Supplier Related

Lp-PLA2 -IN-1

Basic information Safety Supplier Related

Lp-PLA2 -IN-1 Basic information

Product Name:
Lp-PLA2 -IN-1
Synonyms:
  • Lp-PLA2 inhibitor
  • GSK 2814338;GSK-2814338
  • Lp-PLA2 -IN-1
  • Lp-PLA2 inhibitor 1
  • Lp-PLA2 -IN-1(GSK2814338)
  • inhibit,Lp-PLA-2-IN-1,LpPLA2IN1,Inhibitor,Lp PLA2 IN 1,Phospholipase
  • 6H-Pyrimido[1,6-a]pyrimidin-6-one, 8-[[3,5-difluoro-4-[[6-(trifluoromethyl)-3-pyridinyl]oxy]phenyl]methoxy]-1,2,3,4-tetrahydro-1-methyl-
  • 8-((3,5-Difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-1-methyl-1,2,3,4-tetrahydro-6H-pyrimido[1,6-a]pyrimidin-6-one
CAS:
1420367-28-7
MF:
C21H17F5N4O3
MW:
468.38
Mol File:
1420367-28-7.mol
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Lp-PLA2 -IN-1 Chemical Properties

Boiling point:
483.5±55.0 °C(Predicted)
Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Ethanol:25.0(Max Conc. mg/mL);53.38(Max Conc. mM)
pka
3.84±0.40(Predicted)
form 
Solid
color 
White to off-white
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Lp-PLA2 -IN-1 Usage And Synthesis

Uses

Lp-PLA2-IN-1 is a potent Lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor. Lp-PLA2-IN-1 has the potential for atherosclerosis, Alzheimer's disease research[1].

IC 50

Lp-PLA2

References

[1] Zehong Wan, et al. Bicyclic pyrimidone compounds. WO2013014185A1.

Lp-PLA2 -IN-1Supplier

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Lp-PLA2 -IN-1(1420367-28-7)Related Product Information