1-(2-Aminoethyl)imidazolidin-2-one Chemical Properties

Boiling point:

138-140/0.11mm

Density 

1.137±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

viscous oil

pka

14.42±0.20(Predicted)

color 

Orange

InChI

InChI=1S/C5H11N3O/c6-1-3-8-4-2-7-5(8)9/h1-4,6H2,(H,7,9)

InChIKey

PODSUMUEKRUDEI-UHFFFAOYSA-N

SMILES

C1(=O)N(CCN)CCN1

CAS DataBase Reference

6281-42-1(CAS DataBase Reference)

EPA Substance Registry System

2-Imidazolidinone, 1-(2-aminoethyl)- (6281-42-1)

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

34

Safety Statements 

22-26-36/37/39-45

RIDADR 

3259

Hazard Note 

Irritant

HazardClass 

8

HS Code 

29332900

1-(2-Aminoethyl)imidazolidin-2-one Usage And Synthesis

Chemical Properties

Colorless to off-white liquid

Uses

1-(2-Aminoethyl)-2-imidazolidone is a useful research chemical compound used in the preparation of alkyl and aryl azides by chemoselective diazotization of primary amines with in situ-generated fluorosulfonyl azide and their use in the preparation of a combinatorial library of 1,2,3-triazole.

Flammability and Explosibility

Not classified

Synthesis

693 kg (6.728 kmol) of diethylenetriamine (DETA) was added to a 1 m3 stirred reactor equipped with a double jacket, a liquid feed device, a nitrogen inerting system, a reaction vessel, and a scrubber tower for recovery of ammonia and ammonia solution. The reaction system was warmed up to 130°C while nitrogen was introduced to remove oxygen from the DETA. When the temperature reached 130 °C, slow addition of a 40% aqueous urea solution totaling 671.4 kg (4.476 kmol) was initiated, resulting in a molar ratio of DETA to urea of 1.5:1. The addition of the urea solution continued for a period of 4 h in batches. The ammonia released immediately at the beginning of the reaction was recovered through a scrubbing tower, and the scrubbing solution and the aqueous ammonia solution were collected in a special container. After the addition was completed, the reaction mixture was kept at 130°C for 1.5 hours to ensure complete water removal. Subsequently, the reaction temperature was gradually increased: first to 140 °C in 45 min and held for 45 min, then to 150 °C and held for 45 min, and finally at 160 °C for 5 h. The reaction temperature was then increased to 140 °C in 45 min and held for 45 min. At the end of the reaction, the system was cooled to 125 °C and the excess DETA was removed by distillation under a reduced pressure of 10 to 1.5 mbar and a mild nitrogen stream, a process that did not take more than 5 hours. After restoring the system to atmospheric pressure, it was cooled to 60 °C and the product was removed from the reactor. The resulting product contained 95-96% of 1-(2-aminoethyl)-2-imidazolidinone (UDETA) and 1-2.5% of tetraethyleneurea (TETU).

References

[1] Patent: US2013/23667, 2013, A1. Location in patent: Paragraph 0044; 0045; 0046; 0047
[2] Patent: US2613212, 1950,
[3] Patent: US6630599, 2003, B1. Location in patent: Page/Page column 10

1-(2-Aminoethyl)imidazolidin-2-one(6281-42-1)Related Product Information

• Imidazolidinyl urea
• 2-Butanone oxime
• N-Aminoethylpiperazine
• Imidazolidine
• 2-Ethylimidazole
• 3-Aminoacetophenone
• 2-Aminoimidazole hemisulfate
• 1,3-Dimethyl-2-imidazolidinone
• 2-(2-Aminoethylamino)ethanol
• 2-Imidazolidone
• 1-Ethylimidazole
• 1-(2-AMINOETHYL)IMIDAZOLIDIN-2-ONE,1-(2-AMINOETHYL)-2-IMIDAZOLIDONE,1-(BETA-AMINOETHYL)-2-IMIDAZOLIDONE
• Alkylimidazole
• 2-Butanone
• Imidazoline inhibitor
• 1-(2-Aminoethyl)imidazolidin-2-one
• 2-Aminoimidazole