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3-Aminoacetophenone

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3-Aminoacetophenone Basic information

Product Name:
3-Aminoacetophenone
Synonyms:
  • M-AMINOACETOPHENONE
  • M-AMINOACETYLBENZENE
  • M-AMINOPHENYLMETHYLKETONE
  • LABOTEST-BB LTBB000557
  • 3-ACETYLANILINE
  • 3'-AMINOACETOPHENONE
  • 3-AMINOACETOPHENONE
  • 1-(3-aminophenyl)ethanone
CAS:
99-03-6
MF:
C8H9NO
MW:
135.16
EINECS:
202-722-3
Product Categories:
  • Pyridines
  • Aromatic Acetophenones & Derivatives (substituted)
  • FINE Chemical & INTERMEDIATES
  • API intermediates
Mol File:
99-03-6.mol
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3-Aminoacetophenone Chemical Properties

Melting point:
94-98 °C(lit.)
Boiling point:
289-290 °C(lit.)
Density 
1.1031 (rough estimate)
refractive index 
1.5700 (estimate)
Flash point:
289-291°C
storage temp. 
2-8°C
pka
3.41±0.10(Predicted)
color 
Yellow to light brown crystalline powder
Water Solubility 
7.056g/L(37.5 ºC)
Merck 
14,413
BRN 
386009
CAS DataBase Reference
99-03-6(CAS DataBase Reference)
NIST Chemistry Reference
3-Aminoacetophenone(99-03-6)
EPA Substance Registry System
3-Aminoacetophenone (99-03-6)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
36/37-36-26
WGK Germany 
2
RTECS 
AM5800000
Hazard Note 
Irritant
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29223900

MSDS

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3-Aminoacetophenone Usage And Synthesis

Chemical Properties

3-Aminoacetophenone is yellow to light brown crystalline powder

Uses

3'-Aminoacetophenone has potential anti-bacterial properties in addition to being used in the synthesis of selective antagonists at human A2B adenosine receptors. As well, it is used in the synthesis of HIV-1 Integrase Inhibitors.

Synthesis Reference(s)

Synthetic Communications, 26, p. 973, 1996 DOI: 10.1080/00397919608003701

Safety Profile

Moderately toxic by ingestion. Mddly toxic by skin contact. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NO,. See also AROMATIC AMINES.

Purification Methods

Recrystallise it from EtOH or aqueous EtOH (m 99.5o). The thiosemicarbazone has m 202-204o (from EtOH). [Beilstein 14 H 45, 14 IV 96.]

3-Aminoacetophenone Preparation Products And Raw materials

Preparation Products

Raw materials

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