3-Aminoacetophenone Chemical Properties

Melting point:

94-98 °C(lit.)

Boiling point:

289-290 °C(lit.)

Density 

1.1031 (rough estimate)

vapor pressure 

1.319Pa at 25℃

refractive index 

1.5700 (estimate)

Flash point:

289-291°C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

3.41±0.10(Predicted)

color 

Yellow to light brown crystalline powder

Water Solubility 

7.056g/L(37.5 ºC)

Merck 

14,413

BRN 

386009

LogP

0.83

CAS DataBase Reference

99-03-6(CAS DataBase Reference)

NIST Chemistry Reference

3-Aminoacetophenone(99-03-6)

EPA Substance Registry System

3-Aminoacetophenone (99-03-6)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

36/37-36-26

WGK Germany 

2

RTECS 

AM5800000

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29223900

MSDS

• Language:English Provider:m-Aminoacetophenone
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3-Aminoacetophenone Usage And Synthesis

Chemical Properties

3-Aminoacetophenone is yellow to light brown crystalline powder

Uses

3'-Aminoacetophenone has potential anti-bacterial properties in addition to being used in the synthesis of selective antagonists at human A2B adenosine receptors. As well, it is used in the synthesis of HIV-1 Integrase Inhibitors.

Uses

3′-Aminoacetophenone (3-Acetylaniline) was used as reagent during the asymmetric total synthesis of pactamycin. It was used as starting reagent during the synthesis of curcumin mimics with substituted sulfonyl group.

Definition

ChEBI: 3'-Aminoacetophenone is an aromatic ketone.

Synthesis Reference(s)

Synthetic Communications, 26, p. 973, 1996 DOI: 10.1080/00397919608003701

General Description

3′-Aminoacetophenone acts as bifunctional coupling reagent during the synthesis of pyrimidines.

Safety Profile

Moderately toxic by ingestion. Mddly toxic by skin contact. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NO,. See also AROMATIC AMINES.

Purification Methods

Recrystallise it from EtOH or aqueous EtOH (m 99.5o). The thiosemicarbazone has m 202-204o (from EtOH). [Beilstein 14 H 45, 14 IV 96.]

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