3'-Hydroxyacetophenone Chemical Properties

Melting point:

90-95 °C(lit.)

Boiling point:

296 °C(lit.)

Density 

1.1 g/mL at 25 °C(lit.)

vapor pressure 

0.022Pa at 25℃

refractive index 

1,534

Flash point:

296°C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

22g/l

form 

Crystalline Powder

pka

9.19(at 25℃)

color 

Beige-brown

Water Solubility 

Soluble in alcohol. Insoluble in water.

BRN 

2040676

InChIKey

LUJMEECXHPYQOF-UHFFFAOYSA-N

LogP

1.144 at 25℃

CAS DataBase Reference

121-71-1(CAS DataBase Reference)

NIST Chemistry Reference

Ethanone, 1-(3-hydroxyphenyl)-(121-71-1)

EPA Substance Registry System

Ethanone, 1-(3-hydroxyphenyl)- (121-71-1)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

22-24/25-37/39-26-36

WGK Germany 

3

Hazard Note 

Harmful/Irritant

TSCA 

Yes

HS Code 

29143990

MSDS

• Language:English Provider:m-Hydroxyacetophenone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3'-Hydroxyacetophenone Usage And Synthesis

Description

3’-Hydroxyacetophenone is a chemical compound and it is a component of castoreum, the exudate from the castor sacs of the mature beaver. It is used in the synthesis and preparation of chalcones and flavonoids as anti-tuberculosis agents, as well as antileishmanial chaocones.

Chemical Properties

beige-brown crystalline powder

Uses

Useful in the preparation of chalcones, flavonoids, and phenylephrine. It is an active component of castoreum, which is used as a tincture in some perfumes and as a food additive.

Uses

3?Hydroxyacetophenone is used in the preparation of chalcones and flavonoids, which finds application as an anti-tuberculosis agent and antileishmanial chaocones. It is also involved in the preparation of phenylephrine. Further, it is an active component of castoreum, which is used as a tincture in some perfumes and as a food additive.

Uses

3’Hydroxyacetophenone is a chemical reagent used in the synthesis and preparation of chalcones and flavonoids as anti-tuberculosis agents, as well as antileishmanial chaocones.

Preparation

Preparation by diazotization of 3-aminoacetophenone, followed by hydrolysis of the obtained diazonium salt (78–82%).

General Description

3′-Hydroxyacetophenone is an hydroxy-substituted alkyl phenyl ketone.

Flammability and Explosibility

Non flammable

Synthesis

General procedure for the synthesis of 3-hydroxyacetophenone from 3-iodoacetophenone: 3-iodoacetophenone (1.0 mmol), CuCl? (13.4 mg, 0.1 mmol), KOH (336 mg, 6.0 mmol), ethylene glycol (12 μL, 0.2 mmol), and a solvent mixture of DMSO/H?O were sequentially added to the test tube fitted with a magnetic stirrer ( 1.0 mL/0.5 mL). The reaction mixture was placed in a preheated 120 °C oil bath under argon protection and stirred for 24 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was extracted by partitioning with 5% HCl aqueous solution and ethyl acetate. The organic phase was washed sequentially with water and saturated saline, dried over anhydrous MgSO? and concentrated under reduced pressure to remove the solvent. The crude product was further purified by column chromatography (eluent: EtOAc/hexane) to afford the target product 3-hydroxyacetophenone.

References

[1] Journal of the American Chemical Society, 2016, vol. 138, # 41, p. 13493 - 13496
[2] Bulletin of the Korean Chemical Society, 2015, vol. 36, # 12, p. 2833 - 2840
[3] European Journal of Organic Chemistry, 2014, vol. 2014, # 2, p. 315 - 318
[4] European Journal of Organic Chemistry, 2014, vol. 2014, # 2, p. 315 - 318
[5] Synlett, 2016, vol. 27, # 12, p. 1814 - 1819

3'-Hydroxyacetophenone(121-71-1)Related Product Information

• 4'-Chloroacetophenone
• 3-Aminoacetophenone
• 4-Nitroacetophenone
• 3,5-Dihydroxyacetophenone
• 3-Nitroacetophenone
• 4'-Methoxyacetophenone
• Acetophenone
• 4'-Bromoacetophenone
• 6-Chloromethylmorphanthridine
• Eptifibatide non cyclic impurity
• 7-Bromo Epinastine
• Benzamide, N-[(6,11-dihydro-5H-dibenz[b,e]azepin-6-yl)methyl]-2-(hydroxymethyl)-
• L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1→7)-disulfide (9CI)
• Methanone, (2-aminophenyl)phenyl-, hydrazone, (Z)-
• N-[2-(Phenylmethyl)phenyl]-2-chloroacetamide
• L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-, bimol. cyclic (1→1'),(6→6')-bis(disulfide)
• Cyclo(L-Pro-L-Trp-)
• Eptifibatide impurity 3/Deamidated Eptifibatide Impurity/(3R,11S,17S,20S,25aS)-20-((1H-indol-3-yl)Methyl)-17-(carboxymethyl)-11-(4-guanidinobutyl)-1,9,12,15,18,21-hexaoxodocosahydro-1H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosine-3-carbo