4'-Bromoacetophenone Chemical Properties

Melting point:

108-110 °C(lit.)

Boiling point:

255 °C(lit.)

Density 

1.64

refractive index 

1.5540 (estimate)

Flash point:

>230 °F

storage temp. 

Store below +30°C.

solubility 

methanol: 0.1 g/mL, clear

form 

Crystals or Crystalline Flakes

color 

White to light yellow

Water Solubility 

Soluble in Chloroform. Insoluble in water.

Merck 

14,1403

BRN 

386015

InChIKey

WYECURVXVYPVAT-UHFFFAOYSA-N

CAS DataBase Reference

99-90-1(CAS DataBase Reference)

NIST Chemistry Reference

Ethanone, 1-(4-bromophenyl)-(99-90-1)

EPA Substance Registry System

Ethanone, 1-(4-bromophenyl)- (99-90-1)

Safety Information

Hazard Codes 

C,Xi,Xn

Risk Statements 

34-36/38-42/43-36/37/38-22

Safety Statements 

26-36/37/39-45-22-36/37

RIDADR 

UN 3261 8/PG 2

WGK Germany 

2

RTECS 

AM6950000

F 

19-21

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29147090

MSDS

• Language:English Provider:p-Bromoacetophenone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4'-Bromoacetophenone Usage And Synthesis

Chemical Properties

white to light yellow crystals. soluble in alcohol, ether, glacial acetic acid, benzene, carbon disulfide and petroleum ether, insoluble in water. Easy to volatilize with water vapor.

Uses

4'-Bromoacetophenone is an important organic synthesis intermediate, widely used in synthetic medicine, pesticides, dyes, flavors and fragrances, perfumes, Intermediates of Liquid Crystals etc.

Uses

Labeled 4?-Bromoacetophenone possess activity against positive phototaxis of Chlamydomonas cells. A fundamental starting material for organic synthesis.

Preparation

4'-Bromoacetophenone is synthesized by the reaction of bromobenzene and acetic anhydride in the presence of aluminum trichloride.
Add bromobenzene and dry carbon disulfide into the reactor, put in powdered anhydrous aluminum trichloride, heat until it starts to reflux, stop heating, add acetic anhydride dropwise, and then reflux for 1 hour after adding, steam out carbon disulfide, and put it while it is still hot. The reactant was poured into the hydrochloric acid ice-water mixture, filtered to dryness, and distilled under reduced pressure to obtain p-bromoacetophenone.

Synthesis Reference(s)

The Journal of Organic Chemistry, 51, p. 5400, 1986 DOI: 10.1021/jo00376a064
Tetrahedron Letters, 26, p. 4657, 1985 DOI: 10.1016/S0040-4039(00)98778-1

Purification Methods

Crystallise it from EtOH, MeOH or from pet ether (b 80-100o). [Tanner J Org Chem 52 2142 1987, Beilstein 7 IV 647.]

4'-Bromoacetophenone(99-90-1)Related Product Information

• Acetophenone
• 4'-Methoxyacetophenone
• 3-Nitroacetophenone
• Acetylacetone
• Bromobenzene
• L-PICEIN
• 3-Aminoacetophenone
• Acetyl chloride
• 4'-Chloroacetophenone
• 4'-Hydroxyacetophenone
• 4-Nitroacetophenone
• 2',4'-Dichloroacetophenone
• 4'-Methylacetophenone
• 3-BROMOACETOPHENONE,3'-BROMOACETOPHENONE,M-BROMOACETOPHENONE,BROMOACETOPHENONE-3
• OMEGA-BROMOACETOPHENONE,-Bromoacetophenon
• 4,4'-Dibromobenzophenone
• 3-Nitro-4-bromoacetophenone
• 4-BROMOBENZOPHENONE