ETHYL 2-CYANOACETOACETATE Chemical Properties

Boiling point:

105-107°C 15mm

Density 

1.120±0.06 g/cm3(Predicted)

vapor pressure 

14.665Pa at 25℃

pka

4.58±0.46(Predicted)

form 

Liquid

Water Solubility 

Not miscible or difficult to mix in water.

LogP

0.95 at 21.5℃ and pH3.5-3.74

Surface tension

66.9mN/m at 1g/L and 20℃

CAS DataBase Reference

634-55-9

Safety Information

Risk Statements 

20/21/22-41

Safety Statements 

26-36/37/39-39

RIDADR 

3276

HazardClass 

6.1

PackingGroup 

III

MSDS

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ETHYL 2-CYANOACETOACETATE Usage And Synthesis

Uses

It is used as a pharmaceutical intermediate. It is also used in the synthesis of fluorine-containing alkyl 2-cyano-3-oxocarboxylates and also in the syntheses of pyrazolo [1, 2-a] pyrazole and pyrazolo [5, 1-b] [1, 3] oxazine derivatives.

Definition

ChEBI: Ethyl 2-cyanoacetoacetate is an alpha-substituted cyanoacetate ester and an ethyl ester.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 28, p. 453, 1991 DOI: 10.1002/jhet.5570280247

ETHYL 2-CYANOACETOACETATE(634-55-9)Related Product Information

• Ethyl 3-oxo-4-phenylbutanoate
• Sodium cyanoborohydride
• ETHYL 2-CYANOACETOACETATE
• Ethyl acetoacetate
• DIETHYL 2-CYANO-3-OXOSUCCINATE
• CYFLUMETOFEN
• ETHYL 4-CYANOACETOACETATE
• ETHYL Α-CYANOACETOACETATE
• 2-CYANO-3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER
• 3-(4-CHLORO-PHENYL)-2-CYANO-3-OXO-PROPIONIC ACID ETHYL ESTER
• 2-CYANO-3-(2-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• 3-(3-CHLORO-PHENYL)-2-CYANO-3-OXO-PROPIONIC ACID ETHYL ESTER
• 2-CYANO-3-(2,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• 2-CYANO-3-(4-METHOXY-3-NITRO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• 2-CYANO-3-(4-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• 2-CYANO-3-(3,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• 3-(2-CHLORO-PHENYL)-2-CYANO-3-OXO-PROPIONIC ACID ETHYL ESTER