OXAZOLAM METHANOL SOLUTION
OXAZOLAM METHANOL SOLUTION Basic information
- Product Name:
- OXAZOLAM METHANOL SOLUTION
- Synonyms:
-
- Serenal
- Tranquit
- OXAZOLAM METHANOL SOLUTION
- OXAZOLAM--DEA SCHEDULE IV ITEM
- Oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one, 10-chloro-2,3,7,11b-tetrahydro-2-methyl-11b-phenyl- (8CI, 9CI)
- Serenal (Japanese)
- Nebusn
- Toccata
- CAS:
- 24143-17-7
- MF:
- C18H17ClN2O2
- MW:
- 328.79
- EINECS:
- 246-032-0
- Product Categories:
-
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Neurochemicals
- Pharmaceuticals
- Mol File:
- 24143-17-7.mol
OXAZOLAM METHANOL SOLUTION Chemical Properties
- Melting point:
- 187°C
- Boiling point:
- 495.8±45.0 °C(Predicted)
- Density
- 1.2065 (rough estimate)
- refractive index
- 1.5400 (estimate)
- Flash point:
- 11 °C
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 12.85±0.60(Predicted)
- form
- A solid
Safety Information
- Hazard Codes
- F,T
- Risk Statements
- 11-23/24/25-39/23/24/25-36/38-23/25
- Safety Statements
- 16-36/37-45-24
- Toxicity
- LD50 orl-mus: 5200 mg/kg NYKZAU 66,107,70
- DEA Controlled Substances
- CSCN: 2839
CSA SCH: Schedule IV
NARC: No
OXAZOLAM METHANOL SOLUTION Usage And Synthesis
Originator
Serenal,Sankyo,Japan,1970
Uses
A psychotropic agent with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a precursor to the active substance Desmethyldiazepam (D291595).
Definition
ChEBI: Oxazolam is an organic molecular entity and a hemiaminal ether.
Manufacturing Process
To a solution of 12.0 g of 5-chloro-2-chloroacetylaminobenzophenone and 3.2 g of isopropanolamine in 100 ml of ethanol was added 3.3 g of sodium acetate.
The resulting mixture was heated under reflux with stirring for 12 hours. After completion of the reaction, the solvent was distilled off and the residue was extracted with dichloromethane. The extract was washed with water, dried over anhydrous sodium sulfate and the solvent was distilled off.
The residue was recrystallized from ethanol to give 10.6 g of the desired product melting at 186°C to 188.5°C.
Therapeutic Function
Tranquilizer
Safety Profile
Moderately toxic by intraperitoneal route. Mildly toxic by ingestion.An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Clí and NOx.
OXAZOLAM METHANOL SOLUTION(24143-17-7)Related Product Information
- 1-(Benzylamino)propan-2-ol
- OXAZOLAM METHANOL SOLUTION
- 2-(1-phenylethylamino)ethanol
- 2-AMINO-5-CHLOROBENZYL ALCOHOL
- 2-amino-5-chloro-diphenyl methanol
- N-Methyl 4-chloro-2-(methoxymethyl)aniline
- trans-Oxazolam
- 1-(3-Chlorophenyl)-1-ethanol
- 7-CHLORO-2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE
- 2-DIMETHYLAMINOMETHYL-ANILINE
- 2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE
- 2-(DIPHENYLMETHOXY)-N-METHYLETHYLAMINE
- 2-AMINOBENZHYDROL
- 2-(2-HYDROXYETHYLAMINO)-N-PHENYLACETAMIDE
- 2-(2-HYDROXYETHYLAMINO)-N-(4-CHLOROPHENYL)ACETAMIDE
- N1-(3-CHLOROBENZYL)-N1-METHYLETHANE-1,2-DIAMINE
- N-ETHYL-M-CHLOROBENZYLAMINE
- (R,S)-1,3,4,5-TETRAHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE HYDROCHLORIDE