PHENAMIL METHANESULFONATE Chemical Properties

storage temp. 

2-8°C

solubility 

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble2.5mg/mL

form 

solid

color 

yellow

CAS DataBase Reference

1161-94-0

Safety Information

WGK Germany 

3

PHENAMIL METHANESULFONATE Usage And Synthesis

Chemical Properties

off-white to yellow solid

Uses

Phenamil Methanesulfonate Salt induced differentiation and peroxisome proliferator-activator receptor γ expression through ETS variant 4 in mouse preadipocyte

Uses

Phenamil methanesulfonate salt has been used:

• to stimulate adipocyte differentiation in 3T3 cells
• to test its effect on lateral flagella expression in Vibrio shilonii
• in nanoparticle preparation to test its effect on osteo/odontoblastic differentiation

General Description

Phenamil, a derivative of amiloride is an inhibitor of sodium channels including acid sensing ion channel (ASIC) and epithelial sodium channels (ENaC).

Biochem/physiol Actions

Phenamil is an inducer of peroxisome proliferator-activated receptor γ (PPARγ) and inhibits diamine oxidase. By favoring tribbles homolog 3 (Trb3) expression, phenamil holds therapeutic potential to treat pulmonary artery hypertension (PAH) and idiopathic PAH. It is also a bone morphogenetic protein (BMP) activator, which favors osteogenesis and odontogenesis of stem cells.

storage

Store at +4°C

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