PHENAMIL Chemical Properties

Melting point:

>181°C (dec.)

Density 

1.65±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: >15 mg/mL

form 

solid

pka

8.10±0.46(Predicted)

color 

yellow

Safety Information

WGK Germany 

3

PHENAMIL Usage And Synthesis

Uses

Phenamil Methanesulfonate Salt induced differentiation and peroxisome proliferator-activator receptor γ expression through ETS variant 4 in mouse preadipocyte

Definition

ChEBI: Phenylamil is a member of pyrazines and a member of guanidines.

Enzyme inhibitor

This amiloride derivative (FW = 306.73 g/mol; CAS 2038-35-9), also known as 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazine carboxamide, irreversibly inhibits amiloride-sensitive Na+ channels. It is often supplied commercially as the methanesulfonate salt. Na+ channel blockers, such as phenamil and benzamil, are be alsoing explored as a way to counteract the hyperabsorption of NaCl in cystic fibrosis airways. Target(s): diamine oxidase; Na+ channels; and Na+ -driven flagellar motility.

PHENAMIL(2038-35-9)Related Product Information

• phenamil receptor
• PHENAMIL METHANESULFONATE
• 5-AMINOPYRAZINE-2-CARBOXAMIDE
• PHENAMIL
• 6-CHLORO-2-PYRAZINECARBOXAMIDE
• 2-pyrazinoylguanidine
• 2-amino-3-chloro-5-methyl-pyrazine
• 6-CHLORO-3,5-DIAMINO-2-PYRAZINECARBOXAMIDE
• 2,6-Pyrazinediamine(9CI)
• 3-AMINO-6-CHLOROPYRAZINE-2-CARBALDEHYDE
• PHENAMIL METHANESULFONATE
• 5-(N,N-HEXAMETHYLENE)-AMILORIDE
• 2-Amino-5-chloropyrazine
• (PYRAZIN-2-YL)METHANAMINEHYDROCHLORIDE
• 3-AMINO-N-METHYLPYRAZINE-2-CARBOXAMIDE
• 2-Chloro-6-methylpyrazine