TELENZEPINE 2HCL Chemical Properties

Melting point:

263-264°

Boiling point:

544.7±50.0 °C(Predicted)

Density 

1.281±0.06 g/cm3(Predicted)

solubility 

H₂O: >10 mg/mL

pka

12.48±0.20(Predicted)

form 

solid

color 

white

Safety Information

WGK Germany 

3

TELENZEPINE 2HCL Usage And Synthesis

Uses

Telenzepine is an antimuscarinic agent with Kis of 0.94 nM (M1 mAChR) and 17.8 nM (M2 mAChR) binding to muscarinic receptors. Telenzepine effectively blocks synaptic transmission promoted by muscarinic or M1 receptor agonists. Thus, Telenzepine can reduce the amplitude of extracellular slow excitatory postsynaptic potentials (EC50=38 nM) and slow inhibitory postsynaptic potentials (EC50=253 nM)[1].

Definition

ChEBI: 1-methyl-10-[2-(4-methyl-1-piperazinyl)-1-oxoethyl]-5H-thieno[3,4-b][1,5]benzodiazepin-4-one is a benzodiazepine.

References

[1] Telenzepine. IMGT. DOI:10.1016/0014-2999(89)90741-3

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