4-Methyl-1-piperazineethanamine Chemical Properties

Boiling point:

103°C/11.25mm

Density 

0.956±0.06 g/cm3(Predicted)

refractive index 

1.4780

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

liquid

pka

10.11±0.10(Predicted)

color 

Colourless to light yellow

Sensitive 

Air Sensitive

InChI

InChI=1S/C7H17N3/c1-9-4-6-10(3-2-8)7-5-9/h2-8H2,1H3

InChIKey

GOWUDHPKGOIDIX-UHFFFAOYSA-N

SMILES

N1(CCN)CCN(C)CC1

CAS DataBase Reference

934-98-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36/37/39

RIDADR 

2735

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

Ⅲ

HS Code 

29339900

4-Methyl-1-piperazineethanamine Usage And Synthesis

Uses

2-(4-Methylpiperazin-1-yl)ethanamine (cas# 934-98-5) is a useful research chemical.

Chemical Properties

Colorless liquid

Uses

1-(2-Aminoethyl)-4-methylpiperazine is used as pharmaceutical intermediate.

Definition

ChEBI: A N-alkylpiperazine that is piperazine substituted by a methyl and a 2-aminoethyl group at the N atoms respectively.

Synthesis

Step 5. To a stirred suspension of lithium aluminum hydride (3.3 g, 87 mmol) in anhydrous THF (100 mL) was slowly added a solution of 2-(4-methylpiperazin-1-yl)acetonitrile (11.2 g, 80.4 mmol) in anhydrous THF (300 mL) at 0 °C. The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the mixture was cooled in an ice bath and H2O (3.3 mL) and 20% NaOH solution (3.3 mL) were added sequentially. After stirring for 20 minutes, the mixture was filtered and the solvent was evaporated. The residue was dissolved in ethyl acetate and dried with anhydrous sodium sulfate. The solvent was evaporated to dryness to give 2-(4-methylpiperazin-1-yl)ethylamine as an oil (1.15 g, 99%).1H NMR (400 MHz, CDCl3) δ: 2.21 (s, 3H), 2.20-2.60 (m, 10H), 2.71 (t, J=6.0 Hz, 2H).

References

[1] Journal of Medicinal Chemistry, 1999, vol. 42, # 15, p. 2870 - 2880
[2] Patent: WO2013/148365, 2013, A1. Location in patent: Paragraph 0086
[3] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 7, p. 2251 - 2259
[4] Patent: WO2016/16728, 2016, A2. Location in patent: Paragraph 000703; 000704
[5] Patent: WO2005/35532, 2005, A1. Location in patent: Page/Page column 30

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