CUL4A antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Monkey

Background

Cullin-4 is a member of the cullin family of related ubiquitin ligases. A pair of mammalian CUL4 proteins have been identified: CUL4A and CUL4B. The carboxy-terminal CUL4 domain interacts with Rbx1 and E2 enzymes, while the amino-terminal CUL4 domain interacts with the BPB domain of UV-damaged DNA-binding protein DDB1 to form a CUL4-DDB1 ubiquitin ligase complex. This CUL4-DDB1 complex binds a variety of WD40-containing proteins that help to enhance additional substrate recruitment. The CUL4 complex has been shown to target substrates involved in DNA repair, cell cycle progression, transcription, and development.

References

[1] Petroski, M.D. and Deshaies, R.J. (2005) Nat Rev Mol Cell Biol 6, 9-20.
[2] Lee, J. and Zhou, P. (2007) Mol Cell 26, 775-80.
[3] Higa, L.A. and Zhang, H. (2007) Cell Div 2, 5.
[4] Ghosh, P. et al. (2008) Cell Cycle 7, 373-81.
[5] Ohtake, F. et al. (2007) Nature 446, 562-6.
[6] Shiyanov, P. et al. (1999) J Biol Chem 274, 35309-12.

CUL4A antibody()Related Product Information

• CYTIP antibody
• MAP3K4 antibody
• SFRP5 antibody
• DHX38 antibody
• CLDN3 antibody
• ABCD4 ANTIBODY
• FBLN5 antibody
• DNM1 antibody
• PTBP2 antibody
• HTR1A Antibody