OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE Chemical Properties

Melting point:

243-246 °C

Density 

1.402 (estimate)

refractive index 

1.6430 (estimate)

storage temp. 

2-8°C

form 

solid

Appearance

White to off-white Solid

CAS DataBase Reference

53052-06-5

Safety Information

Hazard Codes 

Xi

Safety Statements 

24/25

HazardClass 

IRRITANT

HS Code 

2934999090

MSDS

• Language:English Provider:ACROS

OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE Usage And Synthesis

Chemical Properties

Beige crystalline powder

Synthesis

Step 1: Synthesis of oxazolo[4,5-b]pyridine-2(3H)thione 2-Amino-3-hydroxypyridine (5.0 g, 45.45 mmol) and potassium ethylxanthate (8.0 g, 49.99 mmol) were dissolved in pyridine (50 mL), and the reaction was stirred at 110 °C overnight. Upon completion of the reaction, the mixture was cooled to 0 °C, ice water was added and acidified with concentrated hydrochloric acid. The precipitated solid was collected by filtration and dried under vacuum to afford the target product oxazolo[4,5-b]pyridine-2(3H)thione (6.0 g, 86.95% yield). Product characterization data: 1H NMR (DMSO-d6, 300 MHz): δ 8.24-8.22 (d, 1H), 7.90-7.87 (d, 1H), 7.30-7.26 (m, 1H). LCMS: m/z 153.0 [M + H]+.

References

[1] Patent: WO2015/104688, 2015, A1. Location in patent: Page/Page column 36
[2] Patent: US2016/340366, 2016, A1. Location in patent: Paragraph 0205; 0206
[3] Monatshefte fur Chemie, 2011, vol. 142, # 9, p. 895 - 899
[4] Journal of Organic Chemistry, 1995, vol. 60, # 17, p. 5721 - 5725
[5] European Journal of Medicinal Chemistry, 2005, vol. 40, # 1, p. 15 - 23

OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE(53052-06-5)Related Product Information

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• Oxazolo[4,5-b]pyridine
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• Oxazole-2-carbaldehyde
• 5-ISOXAZOLEMETHANOL
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• Oxazolo[4,5-c]pyridin-2-amine (9CI)
• 2-OXAZOLECARBONITRILE
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• OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE
• 2-(METHYLTHIO)OXAZOLO[4,5-B]PYRIDINE
• BUTTPARK 18\09-08
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