2-(METHYLTHIO)OXAZOLO[4,5-B]PYRIDINE Chemical Properties

Melting point:

59-62°

Boiling point:

288.5±32.0 °C(Predicted)

Density 

1.35±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

-0.41±0.50(Predicted)

Appearance

White to yellow Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36

Safety Statements 

26

HazardClass 

IRRITANT

HS Code 

2934999090

2-(METHYLTHIO)OXAZOLO[4,5-B]PYRIDINE Usage And Synthesis

Synthesis

Step 2: Preparation of 2-(methylthio)oxazolo[4,5-b]pyridine To a stirred solution of oxazolo[4,5-b]pyridine-2(3H)-thione (3.0 g, 19.73 mmol) in ethyl acetate (30 mL) at room temperature was sequentially added potassium carbonate (3.81 g, 27.62 mmol) and iodomethane (3.08 g, 21.71 mmol). The reaction mixture was stirred overnight at room temperature. After completion of the reaction, the mixture was diluted with water (100 mL) and extracted with ethyl acetate (2 x 50 mL). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 2-methylthiooxazolo[4,5-b]pyridine (3.0 g, 93.75% yield). 1H NMR (CDCl3, 300 MHz): δ 8.46-8.44 (d, 1H), 7.71-7.68 (d, 1H), 7.20-7.15 (m, 1H), 2.81 (s, 3H). LCMS: m/z 167.0 [M + H]+.

References

[1] Patent: WO2015/104688, 2015, A1. Location in patent: Page/Page column 36
[2] Patent: US2016/340366, 2016, A1. Location in patent: Paragraph 0207; 0208
[3] Journal of Organic Chemistry, 1995, vol. 60, # 17, p. 5721 - 5725
[4] Ultrasonics Sonochemistry, 2010, vol. 17, # 5, p. 783 - 788
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 5, p. 2075 - 2078

2-(METHYLTHIO)OXAZOLO[4,5-B]PYRIDINE(169205-95-2)Related Product Information

• Lincomycin
• 2-(METHYLTHIO)OXAZOLO[5,4-C]PYRIDINE
• BUTTPARK 18\09-09
• BUTTPARK 17\09-04
• 2-(METHYLTHIO)OXAZOLO[4,5-B]PYRIDINE
• BUTTPARK 18\09-08
• BUTTPARK 18\09-10
• BUTTPARK 17\09-01
• BUTTPARK 24\09-26
• BUTTPARK 24\09-25
• BUTTPARK 18\09-07
• BUTTPARK 17\09-02