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Lincomycin

Basic information Safety Supplier Related

Lincomycin Basic information

Product Name:
Lincomycin
Synonyms:
  • U-10149A
  • LINCOMYCIN STANDARD
  • LINCOMYCIN
  • LYNCOMYCIN
  • Lincomycin HCL Bp98 USP24 EPIII CP2000
  • Lincomycin hydrochoride
  • Lincomycin(baseand/orunspecifiedsalt)
  • Albiotic
CAS:
154-21-2
MF:
C18H34N2O6S
MW:
406.54
EINECS:
205-824-6
Product Categories:
  • 13C & 2H Sugars
  • Carbohydrates & Derivatives
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
154-21-2.mol
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Lincomycin Chemical Properties

Melting point:
148-150°C
Boiling point:
646.8±55.0 °C(Predicted)
Density 
1.1704 (rough estimate)
refractive index 
1.6510 (estimate)
pka
7.6(at 25℃)
NIST Chemistry Reference
Lincomycin(154-21-2)
EPA Substance Registry System
Lincomycin (154-21-2)
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Safety Information

Hazardous Substances Data
154-21-2(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 1gm/kg
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Lincomycin Usage And Synthesis

Description

Lincomycin is an antibiotic active against grampositive bacteria. Occupational exposure occurs in poultry and pig breeders.

Chemical Properties

White Crystalline Solid

Originator

Lincocin,Upjohn,UK,1964

Uses

An antibiotic produced by Streptomyces lincolnensis. Antibacterial

Uses

Lincomycin is a polar, water soluble, broad spectrum antibiotic first isolated from Streptomyces licolnensis by researchers at Upjohn in 1962. Lincomycin was the first of a unique structural class, the lincosamides, containing a rare amino acid, 4-propyl-N-methylproline, coupled to an equally rare aminomethylthio-octopyranoside sugar. Lincomycin and semi-synthetic analogues are often incorrectly considered to be aminoglycosides but share little or no structural similarity. Lincomycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.

Definition

ChEBI: A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis.

Manufacturing Process

As described in US Patent 3,086,912, the process comprises cultivating Streptomyces lincolnensis var. lincolnensis in an aqueous nutrient medium containing a source of assimilable carbohydrate and assimilable nitrogen under aerobic conditions until substantial activity is imparted to the medium by production of lincolnensin and isolating the lincolnensin so produced.

brand name

Lincocin (Pharmacia & Upjohn).

Therapeutic Function

Antibacterial

Contact allergens

Lincomycin is an antibiotic of the lincosanide group,active against Gram-positive bacteria. Occupational exposure occurs in poultry and pig breeders

Clinical Use

Lincomycin is a natural product isolated from fermentations of Streptomyces lincolnensisvar. lincolnensis. It is active against Gram-positive organisms, including some anaerobes. It is indicated for the treatment of serious infections caused by sensitive strains of streptococci, pneumococci, and staphylococci. It generally is reserved for patients who are allergic to penicillin because of the increased risk of pseudomembranous colitis. It also serves as the starting material for the synthesis of clindamycin (by a SN-2 reaction that inverts the R stereochemistry of the C-7 hydroxyl to a C-7 S-chloride).

Veterinary Drugs and Treatments

Lincomycin has dosage forms approved for use in dogs, cats, swine, and in combination with other agents for chickens. Because clindamycin is generally better absorbed, more active, and probably less toxic, it has largely supplanted the use of lincomycin for oral and injectable therapy in small animals, but some clinicians believe that clindamycin does not offer enough clinically significant improvements over lincomycin to justify its higher cost. For further information, refer to the Pharmacology or Doses sections.

Lincomycin Preparation Products And Raw materials

Preparation Products

Lincomycin Supplier

Hubei Moco Chemical Co., Ltd. Gold
Tel
;
Email
3001009495@qq.com;3001039764@qq.com
PI & PI BIOTECH INC. Gold
Tel
020-81716320-
Email
Sales@pipitech.com
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070-
Email
info@chemlin.com.cn
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
BOC Sciences
Email
info@bocsci.com