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Sodium thiosulfate pentahydrate

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Sodium thiosulfate pentahydrate Basic information

Product Name:
Sodium thiosulfate pentahydrate
Synonyms:
  • SodiuM thiosulfate pentahydra
  • SodiuM Thiosulfate, 0.100 N Aqueous Solution, USP VoluMetric SolutionAPHA
  • Sodium thiosulfate pentahydrate 99.999% trace metals basis
  • Sodium thiosulfate pentahydrate ACS reagent, >=99.5%
  • Sodium thiosulfate pentahydrate puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., >=99.5%
  • SODIUM THIOSULFATE PENTAHYDRATE, CRYSTAL LIZED
  • SODIUM THIOSULF. PENTAHYDRATE FOR PHOT&
  • SODIUM THIOSULFATE-5-HYDRATE EXTRA PURE,
CAS:
10102-17-7
MF:
H10Na2O8S2
MW:
248.18
EINECS:
600-156-5
Product Categories:
  • pharmaceutical intermediates
  • INORGANIC & ORGANIC CHEMICALS
  • Inorganics
  • AlphabeticalBiochemicals and Reagents
  • Biochemicals and Reagents
  • Denaturation
  • Disulfide Bridge Cleavage Reagents
  • Metal and Ceramic Science
  • Salts
  • Sodium Salts
  • Inorganic Salts
  • Synthetic Reagents
  • Mass Spectrometry (MS)&LC-MS
  • Reagents for Mass Spectrometry (MS)
  • Inorganic Chemicals
  • Disulfide Bridge Cleavage ReagentsSynthetic Reagents
  • Spectroscopy
  • ACS GradeBiochemicals and Reagents
  • Essential Chemicals
  • Routine Reagents
  • Analytical Reagents for General Use
  • Puriss p.a. ACS
  • Q-S, Puriss p.a. ACS
Mol File:
10102-17-7.mol
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Sodium thiosulfate pentahydrate Chemical Properties

Melting point:
48.5 °C
Boiling point:
100 C
Density 
1.01 g/mL at 25 °C
storage temp. 
Store at +5°C to +30°C.
solubility 
H2O: 1 M at 20 °C, clear, colorless
form 
Solid
Specific Gravity
1.729
color 
White tranparent
Odor
Odorless
PH
6.0-7.5 (100g/l, H2O, 20℃)
PH Range
6 - 8.5
Water Solubility 
680 g/L (20 ºC)
Merck 
14,8694
Stability:
Stable. Incompatible with strong acids, iodine, mercury.
InChIKey
AKHNMLFCWUSKQB-UHFFFAOYSA-L
CAS DataBase Reference
10102-17-7(CAS DataBase Reference)
EPA Substance Registry System
Thiosulfuric acid (H2S2O3), disodium salt, pentahydrate (10102-17-7)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-37/39-36-26
WGK Germany 
1
RTECS 
WE6660000
10
TSCA 
Yes
HS Code 
28323000
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg

MSDS

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Sodium thiosulfate pentahydrate Usage And Synthesis

Chemical Properties

translucent crystals or white powder

Chemical Properties

Sodium thiosulfate occurs as odorless and colorless crystals, a crystalline powder or granules. It is efflorescent in dry air and deliquescent in moist air.

Uses

Titrimetry.

Production Methods

On an industrial scale, sodium thiosulfate is produced chiefly from liquid waste products of sodium sulfide or sulfur dye manufacture. Small-scale synthesis is done by boiling an aqueous solution of sodium sulfite with sulfur.

brand name

Sulfactol (Sterling Winthrop).

Pharmaceutical Applications

Sodium thiosulfate is used as an antioxidant in pharmaceuticals (ophthalmic, intravenous, and oral preparations). It has also been used for its antifungal properties and as a reagent in analytical chemistry.

Safety

Sodium thiosulfate is used in ophthalmic, intravenous, and oral pharmaceutical preparations. Apart from osmotic disturbances, sodium thiosulfate is relatively nontoxic. It is moderately toxic by the subcutaneous route and mildly irritating to respiratory tract and skin. Large oral doses have a cathartic action.
LD50 (IP, mouse) 5.6 g/kg
LD50 (IV, mouse) 2.4 g/kg

storage

Sodium thiosulfate decomposes on heating. The bulk powder should be stored in a cool place, and the container should be kept tightly closed in a dry and well-ventilated place. It should not be stored near acids.

Purification Methods

Crystallise it from EtOH/H2O solutions or from water (0.3mL/g) below 60o by cooling to 0o, and dry it at 35o over P2O5 under vacuum. [Foerster & Mommsen Chem Ber 57 258 1924.] This salt is used as a secondary standard in volumetric analysis [Kilpatrick J Am Chem Soc 45 2132 1923], and is used as “Hypo” in photography [Hargreaves & Dunningham J Soc Chem Ind 42 147T 1923.]

Incompatibilities

Sodium thiosulfate is incompatible with iodine, with acids, and with lead, mercury, and silver salts. It may reduce the activity of some preservatives, including bronopol, phenylmercuric salts, and thimerosal.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (IV solutions; ophthalmic solutions and suspensions; oral capsules, solutions, and tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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