Lincosamides Drugs
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Drug classification： These drugs include two varieties, lincomycin and its semi-synthetic derivatives clindamycin.
Mechanism： Lincosamides mainly act on the 50s ribosomal subunit of bacteria, inhibiting peptide chain extension, interfering protein synthesis of this bacteria and it is a growth phase inhibitor. Antibacterial spectrum is similar to erythromycin, but narrower. The antibacterial spectrums mainly include:
① only staphylococcus (including penicillin-resistant strains), Streptococcus, diphtheria bacillus, Bacillus anthracis and other Gram-positive bacteria.
② anaerobic bacteria, including Bacteroides fragilis, Fusobacterium, digestive bacteria, digestive streptococcus, Clostridium perfringens and so on.
③ Gram-negative aerobic bacteria such as Haemophilus influenzae, Neisseria and Mycoplasma genus which are resistant to this class. Bacteria have complete cross-resistance to lincomycin and clindamycin, and some cross-resistance to erythromycin.
Clinical： These drugs are mainly used for anaerobic bacteria and Gram-positive cocci caused by a variety of infections such as pneumonia, endocarditis, cellulitis, erysipelas, urinary tract infections, and it is a first choice for anaerobic Bacteria-induced infections and Staphylococcus aureus osteomyelitis.
Mechanism： Lincosamides mainly act on the 50s ribosomal subunit of bacteria, inhibiting peptide chain extension, interfering protein synthesis of this bacteria and it is a growth phase inhibitor. Antibacterial spectrum is similar to erythromycin, but narrower. The antibacterial spectrums mainly include:
① only staphylococcus (including penicillin-resistant strains), Streptococcus, diphtheria bacillus, Bacillus anthracis and other Gram-positive bacteria.
② anaerobic bacteria, including Bacteroides fragilis, Fusobacterium, digestive bacteria, digestive streptococcus, Clostridium perfringens and so on.
③ Gram-negative aerobic bacteria such as Haemophilus influenzae, Neisseria and Mycoplasma genus which are resistant to this class. Bacteria have complete cross-resistance to lincomycin and clindamycin, and some cross-resistance to erythromycin.
Clinical： These drugs are mainly used for anaerobic bacteria and Gram-positive cocci caused by a variety of infections such as pneumonia, endocarditis, cellulitis, erysipelas, urinary tract infections, and it is a first choice for anaerobic Bacteria-induced infections and Staphylococcus aureus osteomyelitis.
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- Structure:
- Chemical Name:
- Lincomycin hydrochloride monohydrate
- CAS:
- 7179-49-9
- MF:
- C18H37ClN2O7S
- Structure:
- Chemical Name:
- CLINDAMYCIN HYDROCHLORIDE
- CAS:
- 58207-19-5
- MF:
- C18H34Cl2N2O5S
- Structure:
- Chemical Name:
- Clindamycin phosphate
- CAS:
- 24729-96-2
- MF:
- C18H34ClN2O8PS
- Structure:
- Chemical Name:
- Lincomycin hydrochloride
- CAS:
- 859-18-7
- MF:
- C18H35ClN2O6S
- Structure:
- Chemical Name:
- CLINDAMYCIN 3,4-ISOPROPYLIDENE
- MF:
- C21H37ClN2O5S
- Structure:
- Chemical Name:
- Clindamycin hydrochloride
- CAS:
- 21462-39-5
- MF:
- C18H34Cl2N2O5S
- Structure:
- Chemical Name:
- Clindamycin palmitate hydrochloride
- CAS:
- 25507-04-4
- MF:
- C34H64Cl2N2O6S
- Structure:
- Chemical Name:
- LINCOMYCIN HYDROCHLORIDE
- CAS:
- 17017-22-0
- MF:
- C18H34N2O6S
- Structure:
- Chemical Name:
- Clindamycin
- CAS:
- 18323-44-9
- MF:
- C18H33ClN2O5S
- Structure:
- Chemical Name:
- Lincomycin
- CAS:
- 154-21-2
- MF:
- C18H34N2O6S
- Chemical Name:
- Clindamycin alcoholate
- Chemical Name:
- Clindamycin hydrochlorid capsules
- Chemical Name:
- Clindmycin palmitate hydrochloride
- Chemical Name:
- Clindmycin phosphate hydrochloride
- Structure:
- Chemical Name:
- N-Demethyllincomycin
- CAS:
- 2256-16-8
- MF:
- C17H32N2O6S
- Chemical Name:
- CLINDAMYCIN PHOSPHAT