Dexamethasone EP Impurity E Chemical Properties

Melting point:

228-231 °C(Solv: acetone (67-64-1); hexane (110-54-3))

Boiling point:

548.3±50.0 °C(Predicted)

Density 

1.24±0.1 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Chloroform (Slightly), Dioxane (Slightly), Ethyl Acetate (Slightly)

form 

Solid

pka

12.53±0.70(Predicted)

color 

Pale Yellow

Dexamethasone EP Impurity E Usage And Synthesis

Uses

A related intermediate of Prednisolone (P703740).

Biological Activity

Vamorolone, a synthetic steroid, is an orally available dissociative steroid with anti-inflammatory efficacy. It is a partial agonist of the glucocorticoid receptor (NR3C1) th at appear to be safe and well tolerated. Also, vamorolone is a potent antagonist of the mineralocorticoid receptor (NR3C2). It is under development for children with Duchenne muscular dystrophy.

Toxics Screening Level

The ITSL for 17, 21-dihydroxy-16 alpha-methylpregna-1,4,9 (11)-triene-3, 20-dione has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on annual averaging time.

Dexamethasone EP Impurity E(13209-41-1)Related Product Information

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