16α-Methyl-11-oxo Prednisolone Chemical Properties

Melting point:

197-199°C

Boiling point:

574.4±50.0 °C(Predicted)

Density 

1.28±0.1 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

12.38±0.70(Predicted)

color 

White to Off-White

Major Application

pharmaceutical small molecule

16α-Methyl-11-oxo Prednisolone Usage And Synthesis

Uses

A 16α-substituted Prednisolone as potent topical antiinflammatory agent.

Synthesis

1) Add 5.0 g of pregnane-1,4,16-triene-3,11,20-trione (compound (I-1)) with 0.02 times copper bromide dimethyl sulfide, 1.2 times trimethylchlorosilane, 2 times hexamethylphosphorotriamine to 60 ml of tetrahydrofuran, and slowly add 1.2 times methylmagnesium bromide dissolved in the tetrahydrofuran to carry out the Grignard reaction, the temperature of the reaction is -30??-20??. The reaction was protected by passing N2, and at the end of the reaction it was diluted with water, separated and dried to obtain the Grignard product (compound (II-1)); 2) React the above Grignard with 3 times potassium bicarbonate and 1.5 times m-chloroperoxybenzoic acid in dichloromethane at a reaction temperature of -30 to -25??C, and react until complete. The solution pH was adjusted to 1 with hydrochloric acid, concentrated under reduced pressure, cooled, separated and dried to obtain the compound dexamethasone EP impurity J(III-1), total yield 78.2%.

16α-Methyl-11-oxo Prednisolone(2036-77-3)Related Product Information

• Dexamethasone 21-phosphate disodium salt
• Dexamethasone 21-Propionate
• PSXDNQUHAFMVPT-NWQAGDSVSA-N
• Dexamethasone
• 9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate
• 17β-Carboxy-17-desoxy Dexamethasone
• Dexamethasone-17-acetate
• 17-OXODEXAMETHASONE
• Betamethasone
• 1,2-Dihydro Dexamethasone
• 17,21-Dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate
• Dexamethasone 17-propionate
• 6-hydroxydexamethasone
• Dexamethasone palmitate
• 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate)
• 16-beta Methyl Epoxide
• (11α,16α)-9,11-Epoxy-17,21-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione
• 17,21-dihydroxy-16alpha-methylpregna-1,4,9(11)-triene-3,20-dione