noxytiolin Chemical Properties

Melting point:

88-90°

Boiling point:

203.7±42.0 °C(Predicted)

Density 

1.223±0.06 g/cm3(Predicted)

pka

13.45±0.10(Predicted)

Safety Information

Toxicity

LD50 orally in mice: >3 g/kg (Aebi, Hafstetter)

noxytiolin Usage And Synthesis

Originator

Noxyflex,Geistlich,UK,1964

Definition

ChEBI: Noxytiolin is a member of thioureas.

Manufacturing Process

400 g methyl thiourea and 2.5 g NaHCO3 are dissolved in 400 ml formaldehyde solution of 35% concentration. After having been left at ordinary temperature for 2 to 3 hours, the solution is adjusted with dilute HCl to pH 7 to 7.5. After the reaction mixture had been left overnight at 15°C some of the final product crystallized and was filtered off using a Buchner funnel. The mother liquor was concentrated by evaporation in vacuo at a bath-temperature of 30°C. The crystals obtained were again collected by filtration using a Buchner funnel and were combined with the first crystalline fraction and dried in vacuo at ordinary temperature. Yield of pure substance 400 g; melting point 84°C to 86°C.

Therapeutic Function

Antifungal

noxytiolin(15599-39-0)Related Product Information

• noxytiolin
• THIOPHANAT-ETHYL
• Carbimazole
• Thiophanate-methyl
• DIMETHYLOLTHIOUREA
• 1-(Hydroxymethyl)-4-phenyl-2-tetrazoline-5-thione
• 5-METHYL-2-THIOURIDINE
• 2-THIO-6-AZAURIDINE
• 8-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-N-(4-NITROPHENYL)-1-OXA-4,8-DIAZASPIRO[4.5]DECANE-4-CARBOTHIOAMIDE
• 6-METHOXY-2-THIOXO-2,3-DIHYDRO-1H-PYRIMIDIN-4-ONE
• 4,5-DIMETHOXY-IMIDAZOLIDINE-2-THIONE
• N-ALLYL-8-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1-OXA-4,8-DIAZASPIRO[4.5]DECANE-4-CARBOTHIOAMIDE
• Thibenzazoline
• BUTTPARK 11\07-03
• N-methoxycarbonyl N'-2-nitro-4-trifluoromethylphenyl thiourea
• N-[(1,2,3,4-TETRAHYDROPYRIDO[4,3-B][1,8]NAPHTHYRIDIN-2-YL)THIOCARBONYL]CARBAMIC ACID, ETHYL ESTER
• 4,5-DIHYDROXY-1-PHENYL-IMIDAZOLIDINE-2-THIONE
• 7-AMINO-4-OXO-5-PHENYL-2-THIOXO-1,3,5,8-TETRAHYDRO-8-OXAQUINAZOLINE-6-CARBONITRILE