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noxytiolin

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noxytiolin Basic information

Product Name:
noxytiolin
Synonyms:
  • noxytiolin
  • Noxythiolin
  • 1-(Hydroxymethyl)-3-methylthiourea
  • Gynaflex
  • Noxyflex S
  • Noxytioline
  • (methylamino-λsup4sup-sulfanylidyne)methylamino]methanol
  • Noxythioline
CAS:
15599-39-0
MF:
C3H8N2OS
MW:
120.17
EINECS:
2396795
Mol File:
15599-39-0.mol
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noxytiolin Chemical Properties

Melting point:
88-90°
Boiling point:
203.7±42.0 °C(Predicted)
Density 
1.223±0.06 g/cm3(Predicted)
pka
13.45±0.10(Predicted)
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Safety Information

Toxicity
LD50 orally in mice: >3 g/kg (Aebi, Hafstetter)
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noxytiolin Usage And Synthesis

Originator

Noxyflex,Geistlich,UK,1964

Definition

ChEBI: Noxytiolin is a member of thioureas.

Manufacturing Process

400 g methyl thiourea and 2.5 g NaHCO3 are dissolved in 400 ml formaldehyde solution of 35% concentration. After having been left at ordinary temperature for 2 to 3 hours, the solution is adjusted with dilute HCl to pH 7 to 7.5. After the reaction mixture had been left overnight at 15°C some of the final product crystallized and was filtered off using a Buchner funnel. The mother liquor was concentrated by evaporation in vacuo at a bath-temperature of 30°C. The crystals obtained were again collected by filtration using a Buchner funnel and were combined with the first crystalline fraction and dried in vacuo at ordinary temperature. Yield of pure substance 400 g; melting point 84°C to 86°C.

Therapeutic Function

Antifungal

noxytiolinSupplier

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