4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID& Chemical Properties

Boiling point:

137 °C / 0.7mmHg

Density 

1.361 g/mL at 25 °C

refractive index 

n20/D 1.5488

Flash point:

110 °C

storage temp. 

2-8°C

pka

1.96±0.70(Predicted)

form 

clear liquid

color 

Colorless to Light yellow to Light orange

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

20/21/22-36/37/38-51/53

Safety Statements 

26-61-36/37

RIDADR 

UN 3082 9/PG 3

WGK Germany 

3

HS Code 

29252900

4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID& Usage And Synthesis

Uses

4-Methoxybenzyl-2,2,2-trichloroacetimidate can be used as a reagent for the protection of alcohols as the p-methoxybenzyl ether. 1o, 2o, and 3o alcohols can be easily protected using this reagent with equal efficiency in the presence of a variety of different protective groups. This reagent is commonly used under acidic conditions therefore it offers an alternative method to the Williamson ether synthesis, which is typically used basic conditions to protect base-sensitive alcohols.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID&(89238-99-3)Related Product Information

• 4'-METHOXY-2,2,2-TRIFLUOROACETOPHENONE
• Methoxyacetic acid
• 2-CHLOROETHANESULFONYL CHLORIDE
• BENZYL 2,2,2-TRICHLOROACETIMIDATE
• ETHYL 2,2,2-TRICHLOROACETIMIDATE
• BENZYL 2-CHLOROETHYL ETHER
• 4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID&
• METHYL 2,2,2-TRICHLOROACETIMIDATE