Keverprazan Hydrochloride
Keverprazan Hydrochloride Basic information
- Product Name:
- Keverprazan Hydrochloride
- Synonyms:
-
- 1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl-, hydrochloride (1:1)
- P-CAB agent 2 hydrochloride
- 1-(5-(2-Fluorophenyl)-1-((3-(3-methoxypropoxy)phenyl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine hydrochloride
- Carenoprazan HCl
- CAS:
- 2209911-80-6
- MF:
- C22H26ClFN2O4S
- MW:
- 468.97
- Mol File:
- 2209911-80-6.mol
Keverprazan Hydrochloride Chemical Properties
- form
- Solid
- color
- Off-white to light yellow
Keverprazan Hydrochloride Usage And Synthesis
Uses
P-CAB agent 2 hydrochloride is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 hydrochloride inhibits H+/K+-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 hydrochloride inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 hydrochloride shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion[1].
in vivo
P-CAB agent 2 hydrochloride (example 1) inhibits histamine (HY-B1204)-induced gastric acid secretion in SD rats[1].
P-CAB agent 2 hydrochloride (600, 2000 mg/kg; p.o.; once) shows no acute toxicity and 600mg/kg shows no significant effect on animal body weight in SD rats[1].
| Animal Model: | 180-220 g, SPF grade, male SD rats[1] |
| Dosage: | 2 mg/kg |
| Administration: | P.o.; once |
| Result: | Inhibited histamine-induced gastric acid secretion with the acid suppression rate of 55.4%. |
References
[1] YinLin Qin, et al. Pyrrole sulfonyl derivative, and preparation method and medical use thereof. WO2016119505A1.
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