O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane
O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane Basic information
- Product Name:
- O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane
- Synonyms:
-
- O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane
- AB-182
- Carbamic acid, [[bis(2,2-dimethyl-1-aziridinyl)phosphinyl]oxy]-, ethyl ester (9CI)
- CAS:
- 54805-58-2
- MF:
- C11H22N3O4P
- MW:
- 291.28
- Mol File:
- 54805-58-2.mol
O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane Usage And Synthesis
Description
AB-182 is an aziridine derivative and antitumor agent.
Uses
AB-182 is an aziridine derivative and antitumor agent.AB-182 shows synergistic antitumor effects in conjunction with x-irradiation. Intermediate hydrolysis products of AB-182 may block the repair of x-irradiation-induced breaks in the DNA strands by phosphorylating their free 3'-OH end groups.
References
[1] Bardos TJ, Dunn JA, Perlman ME. Chemical mechanism of the radiation potentiating effects of 2,2-dimethylaziridine-type antitumor agents. Int J Radiat Oncol Biol Phys. 1979;5(9):1653-1656. DOI:10.1016/0360-3016(79)90791-0
[2] Wodinsky I, Clement J, Swiniarski J, Skura A. Combined therapy with an aziridine derivative NSC 200724 (AB182) and radiation on an experimental leukemia. Int J Radiat Oncol Biol Phys. 1979;5(9):1677-1680. DOI:10.1016/0360-3016(79)90796-x
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