Ormutivimab CAS#: 2449086-91-1

Ormutivimab Basic information

Product Name:

Ormutivimab

Synonyms:

Ormutivimab
Research Grade Ormutivimab (DVV03905)
Research Grade Ormutivimab

CAS:

2449086-91-1

MW:

0

Mol File:

Mol File

More

Less

Ormutivimab Usage And Synthesis

Uses

Ormutivimab (rhRIG) is a recombinant human monoclonal antibody, targeting rabies virus. Ormutivimab neutralizes a variety of rabies virus strains. Ormutivimab exhibits potent potency against rabies post-exposure prophylaxis (PEP) model[1][2].

in vivo

Ormutivimab (20 IU/kg; i.m.; single dose) protects beagles from a lethal challenge of street RABV BD06^[1].
Ormutivimab (20 IU/kg, 100 IU/kg; i.m.; single dose) protects challenged Kunming mice against various rabies virus^[1].

Animal Model:	Balb/c mice challenge model with rabies virus^[1]
Dosage:	20 IU/kg, 100 IU/kg
Administration:	Intramuscular injection; single dose after 4 hr after infection
Result:	Protected mice from rabies CVS-24 and GZ-1 isolates at a comparable rate (90%) to that of HRIG, human antirabies immune globulin.

References

[1] Zhai LL, et al. Efficacy of ormutivimab, a novel recombinant human anti-rabies monoclonal antibody, in post-exposure prophylaxis animal models. Travel Med Infect Dis. 2022 Mar-Apr;46:102267. DOI:10.1016/j.tmaid.2022.102267
[2] Zhang J, et al. Population Pharmacodynamic Analyses of Human Anti-Rabies Virus Monoclonal Antibody (Ormutivimab) in Healthy Adult Subjects. Vaccines (Basel). 2022 Jul 29;10(8):1218. DOI:10.3390/vaccines10081218

OrmutivimabSupplier

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Email: 2853530910@QQ.com

Guangzhou Hongyuan Chemical Co.,Ltd

Tel: 15817493340
Email: 981810490@qq.com

Wuhan Chemstan Biotechnology Co., Ltd.

Tel: 027-65317797 15926423062
Email: 422450190@qq.com

Biolab Reagents

Tel: 027-65279366 18108604356
Email: products@biolabreagent.com

Wanxin Biotechnology (Jiaxing) Co., LTD

Tel: 0573-83568680 18057391398
Email: 3956524501@qq.com