(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid Chemical Properties

Melting point:

>160°C (dec.)

Boiling point:

481.1±51.0 °C(Predicted)

Density 

1?+-.0.1 g/cm3(Predicted)

storage temp. 

Refrigerator, under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

pka

2.40±0.10(Predicted)

form 

Solid

color 

White to Off-White

InChI

InChI=1S/C8H9N3O5S/c1-15-5(12)2-16-11-6(7(13)14)4-3-17-8(9)10-4/h3H,2H2,1H3,(H2,9,10)(H,13,14)/b11-6-

InChIKey

AGFYEFQBXHONNW-WDZFZDKYSA-N

SMILES

C(O)(=O)/C(/C1=CSC(N)=N1)=N\OCC(OC)=O

(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid Usage And Synthesis

Uses

(Z)-2-(2-amino-4-thiazolyl)-2-methoxycarbonylmethoxyiminoacetic acid (cefixime side chain acid) is an important side chain for the synthesis of the third and fourth generation cephalosporins It is of great economic and practical value to strengthen its research and development.

Uses

(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid can be used as an intermediate in organic synthesis.

Preparation

The synthesis of cefixime side chain acid takes tert-butyl acetoacetate as raw material, through the steps of oximation, etherification, chlorination, cyclization and hydrolysis, to synthesize (Z)-2-(2-amino Thiazol-4-yl)-2-methoxycarbonylmethoxyiminoacetic acid.

(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid(80544-17-8)Related Product Information

• Ethyl 2-(Chlorosulfonyl)acetate
• Glycine
• Ethyl acetate
• Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT)
• (Z)-2-(TERT-METHOXYCARBONYLMETHOXYIMINO)-2-(2-AMINOTHIAZOL-4-YL)ACETIC ACID
• Chloroacetic acid
• Acetic anhydride
• Cefixime
• 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-[[2-(1,1-DIMETHYLETHOXY)-2-OXOETHOXY]IMINO]-, ANHYDRIDE WITH DIETHYL HYDROGEN PHOSPHATE, (Z)-
• (Z)-2-(2-Aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)acetic acid
• Diethyl thiophosphoryl-(Z)-2-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl)isopropoxyiminoacetate
• (Z)-2-(tert-Butoxycarbonylprop-2-oxyimino)-2-(2-tritylaminothiazol-4-yl)acetic acid
• Ethyl 2-(2-aminothiazole-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetate
• 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-[[2-(1,1-DIMETHYLETHOXY)-1,1-DIMETHYL-2-OXOETHOXY]IMINO]-, ANHYDRIDE WITH DIETHYL HYDROGEN PHOSPHATE, (Z)-
• POLY(METHYL METHACRYLATE) ISOTACTIC
• 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-[[2-(1,1-DIMETHYLETHOXY)-2-OXOETHOXY]IMINO]-, ANHYDRIDE WITH O,O-DIETHYL HYDROGEN PHOSPHOROTHIOATE
• (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid
• (Z)-(METHOXYCARBONYLMETHOXYIMINO)-2-(2-AMINOTHIAZOL-4-YL)ACETIC ACID