(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid
(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid Basic information
- Product Name:
- (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid
- Synonyms:
-
- NICA
- (Z)-2-Amino-ALPHA-[(2-methoxy-2-oxoethoxy)-imino]-4-thiazoleacetic acid
- MICAAcid
- (Z)-2-(2-AMINOTHIAZOL-4-YL)-2-METHOXYCARBONYLMETHOXYIMINOACETIC ACID
- (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid
- (Z)-2-(2-METHOXY-2-OXOETHOXYIMINO)-2-(2-METHYLTHIAZOL-4-YL)ACETIC ACID
- (Z)-(2-Aminothiazol-4-yl)-
- (Z)-2-(2-AMinothiazol-4-yl)-2-((2-Methoxy-2-oxoethoxy)iMino)acetic acid
- CAS:
- 80544-17-8
- MF:
- C8H9N3O5S
- MW:
- 259.24
- Mol File:
- 80544-17-8.mol
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(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid Chemical Properties
- Melting point:
- >160°C (dec.)
- Boiling point:
- 481.1±51.0 °C(Predicted)
- Density
- 1?+-.0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator, under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- pka
- 2.40±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
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(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid Usage And Synthesis
Uses
(Z)-2-(2-amino-4-thiazolyl)-2-methoxycarbonylmethoxyiminoacetic acid (cefixime side chain acid) is an important side chain for the synthesis of the third and fourth generation cephalosporins It is of great economic and practical value to strengthen its research and development.
Uses
(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid can be used as an intermediate in organic synthesis.
Preparation
The synthesis of cefixime side chain acid takes tert-butyl acetoacetate as raw material, through the steps of oximation, etherification, chlorination, cyclization and hydrolysis, to synthesize (Z)-2-(2-amino Thiazol-4-yl)-2-methoxycarbonylmethoxyiminoacetic acid.
(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acidSupplier
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(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid(80544-17-8)Related Product Information
- Ethyl 2-(Chlorosulfonyl)acetate
- Glycine
- Ethyl acetate
- Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT)
- (Z)-2-(TERT-METHOXYCARBONYLMETHOXYIMINO)-2-(2-AMINOTHIAZOL-4-YL)ACETIC ACID
- Chloroacetic acid
- Acetic anhydride
- Cefixime
- 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-[[2-(1,1-DIMETHYLETHOXY)-2-OXOETHOXY]IMINO]-, ANHYDRIDE WITH DIETHYL HYDROGEN PHOSPHATE, (Z)-
- (Z)-2-(2-Aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)acetic acid
- Diethyl thiophosphoryl-(Z)-2-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl)isopropoxyiminoacetate
- (Z)-2-(tert-Butoxycarbonylprop-2-oxyimino)-2-(2-tritylaminothiazol-4-yl)acetic acid
- Ethyl 2-(2-aminothiazole-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetate
- 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-[[2-(1,1-DIMETHYLETHOXY)-1,1-DIMETHYL-2-OXOETHOXY]IMINO]-, ANHYDRIDE WITH DIETHYL HYDROGEN PHOSPHATE, (Z)-
- POLY(METHYL METHACRYLATE) ISOTACTIC
- 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-[[2-(1,1-DIMETHYLETHOXY)-2-OXOETHOXY]IMINO]-, ANHYDRIDE WITH O,O-DIETHYL HYDROGEN PHOSPHOROTHIOATE
- (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid
- (Z)-(METHOXYCARBONYLMETHOXYIMINO)-2-(2-AMINOTHIAZOL-4-YL)ACETIC ACID