4-(2-Bromo-acetyl)-benzoic acid Chemical Properties

Melting point:

224-225℃ (methanol )

Boiling point:

386.2±22.0 °C(Predicted)

Density 

1.657±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

pka

3.68±0.10(Predicted)

color 

Off-white

Safety Information

RIDADR 

1759

HazardClass 

8

PackingGroup 

Ⅲ

HS Code 

2918290090

4-(2-Bromo-acetyl)-benzoic acid Usage And Synthesis

Uses

A phenacyl bromide

Synthesis

General procedure for the synthesis of 4-(2-bromoacetyl)benzoic acid from 4-acetylbenzoic acid: 1 mmol of 4-acetylbenzoic acid was dissolved in 10 mL of acetic acid (AcOH). Subsequently, 1 equivalent of bromine was dissolved in 10 mL of acetic acid (AcOH) and added dropwise to the reaction mixture. The reaction mixture was stirred at room temperature for 4 hours. After completion of the reaction, the solvent was evaporated to dryness. The product was purified by normal phase column chromatography using a gradient increasing dichloromethane solution of methanol as eluent.

References

[1] Journal of the American Chemical Society, 2000, vol. 122, # 39, p. 9361 - 9366
[2] European Journal of Medicinal Chemistry, 2014, vol. 77, p. 361 - 377
[3] Russian Journal of Applied Chemistry, 2007, vol. 80, # 4, p. 571 - 575
[4] Bioorganic and Medicinal Chemistry, 1997, vol. 5, # 3, p. 601 - 621
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 24, p. 7520 - 7534

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