3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid Chemical Properties

Boiling point:

483.9±45.0 °C(Predicted)

Density 

1.485±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

3.82±0.20(Predicted)

Appearance

White to yellow Solid

Safety Information

HazardClass 

IRRITANT

HS Code 

2934999090

3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid Usage And Synthesis

Synthesis

The general procedure for the synthesis of 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid from ethyl 3-oxo-4H-1,4-benzothiazine-6-carboxylate was as follows: to a solution of tetrahydrofuran (THF, 30 mL) of ethyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate (5.1 g, 21 mmol), 1 N aqueous sodium hydroxide solution (100 mL). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the reaction solution was acidified with 1 N hydrochloric acid and subsequently extracted with ethyl acetate. The organic phases were combined, washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting residue was recrystallized with diisopropyl ether to give the title compound as white crystals (3.65 g, 83% yield).1H NMR (300 MHz, DMSO-d6) δ: 3.26 (br, 1H), 3.48 (s, 2H), 7.34-7.51 (m, 3H), 10.69 (br, 1H).

References

[1] Patent: WO2004/46107, 2004, A1. Location in patent: Page 213

3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid(272437-84-0)Related Product Information

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