Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Chemical Properties

Melting point:

180-182°

Boiling point:

435.7±45.0 °C(Predicted)

Density 

1.343±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

Solid

pka

12.34±0.20(Predicted)

Appearance

White to off-white Solid

CAS DataBase Reference

188614-01-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2934999090

Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Usage And Synthesis

Synthesis

GENERAL METHOD: A suspension of methyl 3-iodo-4-aminobenzoate (1 mmol), methyl thioglycolate (1.5 eq.), cuprous(I) iodide (0.05 mmol), trans-N,N'-dimethylcyclohexane-1,2-diamine (0.1 mmol), and cesium carbonate (2 eq.) in anhydrous 1,4-dioxane (4 mL) was added to a vial. Nitrogen was passed into the suspension to degas it for 3 min under stirring. Subsequently, the vial was sealed. The reaction mixture was heated at 100 °C (oil bath temperature) for 15 hours. After completion of the reaction, it was cooled to room temperature and filtered. The filtrates were combined and concentrated using a rotary evaporator and the resulting residue was purified by silica gel column chromatography (eluent: 5% dichloromethane solution in methanol) to afford the target product, methyl 3-carbonyl-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate, as a beige solid.

References

[1] Tetrahedron Letters, 2013, vol. 54, # 38, p. 5214 - 5216

Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate(188614-01-9)Related Product Information

• 1,1'-Carbonyldiimidazole
• Kresoxim-methyl
• Methyl acrylate
• RESMETHRIN
• Methyl acetate
• Benzo[b]thien-2-ylboronic acid
• Bensulfuron methyl
• Methylparaben
• Thiophanate-methyl
• Methyl
• Carbonyl iron powder
• NICKEL CARBONYL
• Parathion-methyl
• Methyl bromide
• 4-(4-OXO-PIPERIDINE-1-CARBONYL)-BENZAMIDE
• METHYL 4-METHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE-6-CARBOXYLATE
• Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate
• METHYL 4-ETHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE-6-CARBOXYLATE