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1,1'-Carbonyldiimidazole

Basic information Safety Supplier Related

1,1'-Carbonyldiimidazole Basic information

Product Name:
1,1'-Carbonyldiimidazole
Synonyms:
  • CARBONYLDIIMIDAZOLE
  • CARBODIIMIDAZOLE
  • LABOTEST-BB LT00233203
  • IM2 C O
  • DI(1H-IMIDAZOL-1-YL)METHANONE
  • CDI
  • (DIIMIDAZOL-1-YL)KETONE
  • AKOS BBS-00004316
CAS:
530-62-1
MF:
C7H6N4O
MW:
162.15
EINECS:
208-488-9
Product Categories:
  • Zero-Length Crosslinker
  • blocks
  • AMIDE
  • BuildingBlocks
  • Peptide
  • pharma material
  • Imidazoles
  • Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines
  • Peptide Coupling Reagents
  • Biochemistry
  • Condensation & Active Esterification
  • Coupling Reactions (Peptide Synthesis)
  • Heterocycles
  • Intermediates
  • Peptide Synthesis
  • Synthetic Organic Chemistry
  • VX:15689727968
Mol File:
530-62-1.mol
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1,1'-Carbonyldiimidazole Chemical Properties

Melting point:
117-122 °C(lit.)
Boiling point:
288.83°C (rough estimate)
Density 
1.303 g/mL at 25 °C
refractive index 
n20/D1.434
storage temp. 
2-8°C
solubility 
Soluble in dimethylformamide.
pka
2.90±0.10(Predicted)
form 
Crystalline Powder
color 
White to light cream
PH
7.7 (50g/l, H2O, 20℃)
PH Range
7.7 at 50 g/l
Water Solubility 
Insoluble in water
Sensitive 
Moisture Sensitive
Merck 
14,1819
BRN 
6826
Stability:
Stable, but moisture-sensitive. Incompatible with acids, strong oxidizing agents, water.
InChIKey
PFKFTWBEEFSNDU-UHFFFAOYSA-N
CAS DataBase Reference
530-62-1(CAS DataBase Reference)
EPA Substance Registry System
1H-Imidazole, 1,1'-carbonylbis- (530-62-1)
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Safety Information

Hazard Codes 
C,Xi,Xn
Risk Statements 
22-34-36/37/38-40-36/38
Safety Statements 
26-36/37/39-45-37/39-27-36/37
RIDADR 
UN 3263 8/PG 2
WGK Germany 
2
10-21
Hazard Note 
Harmful/Corrosive/Moisture Sensitive
TSCA 
T
HazardClass 
8
PackingGroup 
III
HS Code 
29332990
Toxicity
LD50 orally in Rabbit: 1071 mg/kg

MSDS

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1,1'-Carbonyldiimidazole Usage And Synthesis

Chemical Properties

White crystalline powder

Uses

Used in the synthesis of peptides. Contains up to 10% imidazole.

Uses

peptide coupling reagent

Uses

CDI is mainly employed to convert alcohols and amines into carbamates, esters, and ureas. It is also used in the synthesis of peptides and nucleoside triphosphates.

Uses

1,1'-Carbonyldiimidazole is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.

Purification Methods

Crystallise it from *benzene or tetrahydrofuran in a dry-box and store it dry. [Hearn Methods Enzymol 135 102 1987, Beilstein 23/4 V 245.]

1,1'-CarbonyldiimidazoleSupplier

Shanghai Ze Chong Pharmaceutical Technology Co., Ltd. Gold
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186-21330623- ;199-46064200-
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sales@zechongchem.com;angel@zechongchem.com
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caixm@kailechem.com
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0512-62388427- ;
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longchengnmt@gmail.com;longchengnmt@gmail.com
Nantong Xiaochang Pharmaceutical Trading Co., Ltd. Gold
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0513-82104991- ;0513-82104991- ;
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